Reference Report

Reference
Citation	Sieber, M.H., Thummel, C.S. (2009). The DHR96 nuclear receptor controls triacylglycerol homeostasis in Drosophila. Cell Metab. 10(6): 481--490. (Export to RIS)
FlyBase ID	FBrf0209412
Publication Type	Research paper
PubMed ID	19945405
PubMed Abstract	Triacylglycerol (TAG) homeostasis is an integral part of normal physiology and essential for proper energy metabolism. Here we show that the single Drosophila ortholog of the PXR and CAR nuclear receptors, DHR96, plays an essential role in TAG homeostasis. DHR96 mutants are sensitive to starvation, have reduced levels of TAG in the fat body and midgut, and are resistant to diet-induced obesity, while DHR96 overexpression leads to starvation resistance and increased TAG levels. We show that DHR96 function is required in the midgut for the breakdown of dietary fat and that it exerts this effect through the CG5932 gastric lipase, which is essential for TAG homeostasis. This study provides insights into the regulation of dietary fat metabolism in Drosophila and demonstrates that the regulation of lipid metabolism is an ancestral function of the PXR/CAR/DHR96 nuclear receptor subfamily.
DOI	10.1016/j.cmet.2009.10.010
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Cell Metab.
Title	Cell Metabolism
Publication Year	2005-
ISBN/ISSN	1550-4131
Data from Reference
Alleles (12)
	AkhR² bmm¹ Hr96^1.3' Hr96^1.5' Hr96^+tHa Hr96^Scer\UAS.cHa Lsd-2^KG00149 mag^NIG.5932R mag^Scer\UAS.cSa Scer\GAL4^Act5C.PI Scer\GAL4^Cg.PA Scer\GAL4^mex1.2.1
Constructs (7)
	P{Act5C-GAL4-w} P{Cg-GAL4.A} P{Hr96^+tHa} P{mex1-GAL4.2.1} P{NIG.5932R} P{UAS-Hr96.H} P{UAS-mag.S}
Genes (30)
	AkhR bmm CG5322 CG9463 CG9466 CG9468 CG13325 CG15533 CG15534 CG31091 FANCI Fbp1 Hr96 Jon65Ai Jon65Aii LM408 Lsd-2 Lsp1γ Lsp2 mag Mal-B1 Mal-B2 Mdr50 Npc1b Npc2c Npc2d Npc2e Npc2g Npc2h Scer\GAL4
Insertions (1)
	P{Act5C-GAL4-w}E1
Natural transposons (1)
	P-element