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Citation
Sieber, M.H., Thummel, C.S. (2009). The DHR96 nuclear receptor controls triacylglycerol homeostasis in Drosophila.  Cell Metab. 10(6): 481--490.
FlyBase ID
FBrf0209412
Publication Type
Research paper
Abstract

Triacylglycerol (TAG) homeostasis is an integral part of normal physiology and essential for proper energy metabolism. Here we show that the single Drosophila ortholog of the PXR and CAR nuclear receptors, DHR96, plays an essential role in TAG homeostasis. DHR96 mutants are sensitive to starvation, have reduced levels of TAG in the fat body and midgut, and are resistant to diet-induced obesity, while DHR96 overexpression leads to starvation resistance and increased TAG levels. We show that DHR96 function is required in the midgut for the breakdown of dietary fat and that it exerts this effect through the CG5932 gastric lipase, which is essential for TAG homeostasis. This study provides insights into the regulation of dietary fat metabolism in Drosophila and demonstrates that the regulation of lipid metabolism is an ancestral function of the PXR/CAR/DHR96 nuclear receptor subfamily.

PubMed ID
PubMed Central ID
PMC2803078 (PMC) (EuropePMC)
Related Publication(s)
Note

Putting the brakes on dietary fat breakdown.
Kühnlein, 2009, Cell Metab. 10(6): 438--439 [FBrf0209423]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell Metab.
    Title
    Cell Metabolism
    Publication Year
    2005-
    ISBN/ISSN
    1550-4131
    Data From Reference
    Alleles (11)
    Genes (30)
    Natural transposons (1)
    Insertions (1)
    Experimental Tools (2)
    Transgenic Constructs (7)