Reference Report

Reference
Citation	Baumgardt, M., Karlsson, D., Terriente, J., Díaz-Benjumea, F.J., Thor, S. (2009). Neuronal subtype specification within a lineage by opposing temporal feed-forward loops. Cell 139(5): 969--982. (Export to RIS)
FlyBase ID	FBrf0209429
Publication Type	Research paper
PubMed ID	19945380
PubMed Abstract	Neural progenitors generate distinct cell types at different stages, but the mechanisms controlling these temporal transitions are poorly understood. In the Drosophila CNS, a cascade of transcription factors, the "temporal gene cascade," has been identified that acts to alter progenitor competence over time. However, many CNS lineages display broad temporal windows, and it is unclear how broad windows progress into subwindows that generate unique cell types. We have addressed this issue in an identifiable Drosophila CNS lineage and find that a broad castor temporal window is subdivided by two different feed-forward loops, both of which are triggered by castor itself. The first loop acts to specify a unique cell fate, whereas the second loop suppresses the first loop, thereby allowing for the generation of alternate cell fates. This mechanism of temporal and "subtemporal" genes acting in opposing feed-forward loops may be used by many stem cell lineages to generate diversity.
DOI	10.1016/j.cell.2009.10.032
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Secondary IDs
Language of Publication	English
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Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (2)
	Df(2R)Pcl7B Df(3R)Dl-KX23
Alleles (24)
	ap^Scer\UAS.cOa Avic\GFP^{EGFP.nls.Scer\UAS.T:Hsap\MYC} Avic\GFP^{Scer\UAS.T:Mmmm\c-Ha-Ras,T:Hsap\MYC} cas^Scer\UAS.cKa cas^Δ1 cas^Δ3 cas^Δ4 dimm^{Scer\UAS.T:Hsap\MYC} Ecol\lacZ^ap-rK568 Ecol\lacZ^gsb-01155 Ecol\lacZ^lb.K grh^IM grh^Scer\UAS.cBa kn^Scer\UAS.cVa nab^R52 nab^Scer\UAS.cFa nab^SH143 Scer\GAL4^ap-md544 Scer\GAL4^elav-C155 Scer\GAL4^lbe.K Scer\GAL4^pros.PMG Scer\GAL4^sqz-GAL4 sqz^ie sqz^Scer\UAS.cAa
Constructs (12)
	P{GAL4-pros.MG} P{lbe-GAL4.K} P{lb-lacZ.K} P{UAS-ap.O} P{UAS-cas.K} P{UAS-dimm.MYC} P{UAS-EGFP.F.MYC} P{UAS-grh.B} P{UAS-kn.V} P{UAS-nab.PF} P{UAS-nls-myc-EGFP} P{UAS-sqz.A}
Genes (18)
	ap Avic\GFP cas dac dimm dpn Ecol\lacZ eya Fmrf grh gsb-n kn lbe Mad nab Nplp1 Scer\GAL4 sqz
Insertions (5)
	P{GawB}ap^md544 P{GawB}elav^C155 P{GawB}sqz^GAL4 P{PZ}ap^rK568 P{PZ}gsb⁰¹¹⁵⁵
Natural transposons (1)
	P-element