Reference Report

Reference
Citation	Chung, S., Vining, M.S., Bradley, P.L., Chan, C.C., Wharton, K.A., Andrew, D.J. (2009). Serrano (sano) functions with the planar cell polarity genes to control tracheal tube length. PLoS Genet. 5(11): e1000746. (Export to RIS)
FlyBase ID	FBrf0209469
Publication Type	Research paper
PubMed ID	19956736
PubMed Abstract	Epithelial tubes are the functional units of many organs, and proper tube geometry is crucial for organ function. Here, we characterize serrano (sano), a novel cytoplasmic protein that is apically enriched in several tube-forming epithelia in Drosophila, including the tracheal system. Loss of sano results in elongated tracheae, whereas Sano overexpression causes shortened tracheae with reduced apical boundaries. Sano overexpression during larval and pupal stages causes planar cell polarity (PCP) defects in several adult tissues. In Sano-overexpressing pupal wing cells, core PCP proteins are mislocalized and prehairs are misoriented; sano loss or overexpression in the eye disrupts ommatidial polarity and rotation. Importantly, Sano binds the PCP regulator Dishevelled (Dsh), and loss or ectopic expression of many known PCP proteins in the trachea gives rise to similar defects observed with loss or gain of sano, revealing a previously unrecognized role for PCP pathway components in tube size control.
DOI	10.1371/journal.pgen.1000746
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Language of Publication	English
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Publication Type	Journal
Abbreviation	PLoS Genet.
Title	PLoS Genetics
Publication Year	2005-
ISBN/ISSN	1553-7404 1553-7390
Data from Reference
Aberrations (2)
	Df(2L)Exel8003 Df(3L)H99
Alleles (45)
	dgo³⁸⁰ ds^33k dsh¹ dsh^Scer\UAS.cAa Ecol\lacZ^HLHmδ.0.5 Ecol\lacZ^sano-rp395 esg^35Ce-1 fj^d1 ft⁸ ft^G-rv fz²¹ fz³⁰ fz^{arm.T:Avic\GFP-EGFP} pk^eq pk^pk-sple-13 Rho1^72F Rho1^72O rok² sano^hs.PC sano^KO1 sano^KO2 sano^KO3 sano^rp395 sano^{Scer\SceI.RS.cCa} sano^Scer\UAS.cCa sano^{Scer\UAS.T:Avic\GFP} sano^{Scer\UAS.T:Ivir\HA1} sano^unspecified Scer\GAL4^btl.PS Scer\GAL4^Bx-MS1096 Scer\GAL4^hs.2sev Scer\GAL4^ptc-559.1 Scer\GAL4^sage.PV Scr⁴ Scr^hs.PZ sim² sqh^AX3 stan¹⁹² stan^E59 trh¹ Vang^stbm-6 w^+mC w^+mW.hs zip¹ zip²
Constructs (12)
	P{arm-fz.GFP} P{FRT(sano.Scer\SceI.RS)} P{GAL4-btl.S} P{GAL4-Hsp70.sev} P{HLHmδ-lacZ.0.5} P{hs-sano.C} P{HS-Scr.Z} P{sage-GAL4.V} P{UAS-dsh.A} P{UAS-sano.C} P{UAS-sano.GFP} P{UAS-sano.HA}
Genes (45)
	apt B-H1 bnl btl cora crb CrebA dgo dnd ds dsh dys E(spl)mδ-HLH Ecol\lacZ elav esg Fas3 fj fkh ft fz hkb Nrx-IV pk rho Rho1 rok sano sas Scer\GAL4 Scr shg sim sqh stan T:Avic\GFP T:Ivir\HA1 tgo trh Vang verm vvl w zip α-Spec
Insertions (3)
	P{GawB}Bx^MS1096 P{GawB}ptc^559.1 P{lacZ}sano^rp395
Natural transposons (1)
	P-element