Reference Report

Reference
Citation	Furukubo-Tokunaga, K., Adachi, Y., Kurusu, M., Walldorf, U. (2009). Brain patterning defects caused by mutations of the twin of eyeless gene in Drosophila melanogaster. Fly 3(4): 263--269. (Export to RIS)
FlyBase ID	FBrf0209574
Publication Type	Research paper
PubMed ID	19901536
PubMed Abstract	The Drosophila Pax6 genes, eyeless (ey) and twin of eyeless (toy), are expressed in both eyes and the brain. Previous studies have demonstrated that ey plays important roles in axonal outgrowth and differentiation of mushroom bodies (MBs), which are centers for associative learning and memory in flies. However, the functional significance of toy in brain development is poorly understood. Here, we describe the expression patterns of TOY, and show that TOY expression partially overlaps with EY expression in the embryonic, larval and adult brains. Mutations of toy perturb brain neuromere formation in the embryonic stages, and result in severe deformation of the MB lobes in pharate adult brains. Moreover, we also analyzed toy functions by gain-of-function experiments, and show that overexpression of toy results in degeneration of MB lobes. Thus, our results demonstrate the importance of toy in embryonic brain patterning as well as in post-embryonic development of the major brain structures such as MBs.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Fly
Title	Fly
Publication Year	2007-
ISBN/ISSN	1933-6934 1933-6942
Data from Reference
Aberrations (1)
	Df(2L)dac-4
Alleles (6)
	ey^J5.71 ey^Scer\UAS.cHa Scer\GAL4^ey-OK107 toy^{dsRNA.Scer\UAS} toy^hdl toy^Scer\UAS.cCa
Constructs (3)
	P{UAS-ey.H} P{UAS-toy.C} P{UAS-toy.RNAi}
Genes (5)
	dac ey Fas2 Scer\GAL4 toy
Insertions (3)
	P{GawB}ey^OK107 P{UAS-toy.C}U08 P{UAS-toy.C}U011
Natural transposons (1)
	P-element