Reference Report

Reference
Citation	Nagoshi, E., Sugino, K., Kula, E., Okazaki, E., Tachibana, T., Nelson, S., Rosbash, M. (2010). Dissecting differential gene expression within the circadian neuronal circuit of Drosophila. Nat. Neurosci. 13(1): 60--68. (Export to RIS)
FlyBase ID	FBrf0209632
Publication Type	Research paper
PubMed ID	19966839
PubMed Abstract	Behavioral circadian rhythms are controlled by a neuronal circuit consisting of diverse neuronal subgroups. To understand the molecular mechanisms underlying the roles of neuronal subgroups within the Drosophila circadian circuit, we used cell-type specific gene-expression profiling and identified a large number of genes specifically expressed in all clock neurons or in two important subgroups. Moreover, we identified and characterized two circadian genes, which are expressed specifically in subsets of clock cells and affect different aspects of rhythms. The transcription factor Fer2 is expressed in ventral lateral neurons; it is required for the specification of lateral neurons and therefore their ability to drive locomotor rhythms. The Drosophila melanogaster homolog of the vertebrate circadian gene nocturnin is expressed in a subset of dorsal neurons and mediates the circadian light response. The approach should also enable the molecular dissection of many different Drosophila neuronal circuits.
DOI	10.1038/nn.2451
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Nat. Neurosci.
Title	Nature Neuroscience
Publication Year	1998-
ISBN/ISSN	1097-6256
Data from Reference
Aberrations (2)
	Df(3R)sbd45 Df(3R)sbd104
Alleles (9)
	Avic\GFP^{2x.EYFP.Scer\UAS} cu^GD8898 cu^NIG.31299R Fer2^e03248 Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Scer\GAL4^elav-C155 Scer\GAL4^P2.4.Pdf Scer\GAL4^tim.PE Scer\GAL80^Pdf.PS
Constructs (7)
	P{GAL4-tim.E} P{GD8898} P{NIG.31299R} P{Pdf-GAL4.P2.4} P{Pdf-GAL80.S} P{UAS-2xEYFP} P{UAS-mCD8::GFP.L}
Genes (64)
	Avic\GFP bnb cbt CG2254 CG4408 CG5001 CG6310 CG6749 CG7272 CG8745 CG10089 CG10508 CG11762 CG13054 CG13594 CG14086 CG14292 CG15201 CG15408 CG30017 CG30282 CG31324 CG31475 CG31705 CG33988 CG42268 CG42337 CG43658 CG44153 Clk cry cu cwo cyc Cyp6g2 Cyp12e1 Eip63F-1 Fer2 Fkbp13 GstE14 Hr51 Idgf3 Irk1 jhamt MFS3 Mmus\Cd8a moody MtnA nvd Pdf Pdp1 per phm Pkg21D Reck sad Scer\GAL4 Scer\GAL80 sfl Side sro Thor tim vri
Insertions (2)
	P{GawB}elav^C155 PBac{RB}Fer2^e03248
Natural transposons (1)
	P-element