Reference Report

Reference
Citation	Okamoto, N., Yamanaka, N., Yagi, Y., Nishida, Y., Kataoka, H., O'Connor, M.B., Mizoguchi, A. (2009). A fat body-derived IGF-like peptide regulates postfeeding growth in Drosophila. Dev. Cell 17(6): 885--891. (Export to RIS)
FlyBase ID	FBrf0209709
Publication Type	Research paper
PubMed ID	20059957
PubMed Abstract	Members of the insulin family of peptides have conserved roles in the regulation of growth and metabolism in a wide variety of metazoans. Here we show that Drosophila insulin-like peptide 6 (DILP6), which is structurally similar to vertebrate insulin-like growth factor (IGF), is predominantly expressed in the fat body, a functional equivalent of the vertebrate liver and adipocytes. This expression occurs during the postfeeding stage under the direct regulation of ecdysteroid. We further reveal that dilp6 mutants show growth defects during the postfeeding stage, which results in reduced adult body size through a decrease in cell number. This phenotype is rescued by fat body-specific expression of dilp6. These data indicate that DILP6 is a functional, as well as a structural, counterpart of vertebrate IGFs. Our data provide in vivo evidence for a role of ILPs in determining adult body size through the regulation of postfeeding growth.
DOI	10.1016/j.devcel.2009.10.008
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Cell
Title	Developmental Cell
Publication Year	2001-
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Data from Reference
Aberrations (2)
	Df(1)Ilp6-3932 Df(1)Ilp6⁴⁵⁹¹
Alleles (8)
	EcR^{B1-ΔC655.F645A.Scer\UAS} EcR^{B1-ΔC655.W650A.Scer\UAS} EcR^GD1428 Ilp6⁴⁵⁹¹ Ilp6^Scer\UAS.cIa phl^Ilp6-4591 Scer\GAL4^Cg.PA Scer\GAL4^Lsp2.PH
Constructs (7)
	P{?SUPor-P} P{Cg-GAL4.A} P{GD1428} P{Lsp2-GAL4.H} P{UAS-EcR.B1-ΔC655.F645A} P{UAS-EcR.B1-ΔC655.W650A} P{UAS-Ilp6.I}
Genes (13)
	CG2854 CG14050 CR33218 EcR Ilp1 Ilp2 Ilp3 Ilp4 Ilp5 Ilp6 Ilp7 phl Scer\GAL4
Insertions (2)
	P{?SUPor-P}Ilp6-3932 P{SUPor-P}phl^KG04972