Reference Report

Reference
Citation	Haussmann, I.U., White, K., Soller, M. (2008). Erect wing regulates synaptic growth in Drosophila by integration of multiple signaling pathways. Genome Biol. 9(4): R73. (Export to RIS)
FlyBase ID	FBrf0209726
Publication Type	Research paper
PubMed ID	18419806
PubMed Abstract	Formation of synaptic connections is a dynamic and highly regulated process. Little is known about the gene networks that regulate synaptic growth and how they balance stimulatory and restrictive signals.Here we show that the neuronally expressed transcription factor gene erect wing (ewg) is a major target of the RNA binding protein ELAV and that EWG restricts synaptic growth at neuromuscular junctions. Using a functional genomics approach we demonstrate that EWG acts primarily through increasing mRNA levels of genes involved in transcriptional and post-transcriptional regulation of gene expression, while genes at the end of the regulatory expression hierarchy (effector genes) represent only a minor portion, indicating an extensive regulatory network. Among EWG-regulated genes are components of Wingless and Notch signaling pathways. In a clonal analysis we demonstrate that EWG genetically interacts with Wingless and Notch, and also with TGF-beta and AP-1 pathways in the regulation of synaptic growth.Our results show that EWG restricts synaptic growth by integrating multiple cellular signaling pathways into an extensive regulatory gene expression network.
DOI	10.1186/gb-2008-9-4-r73
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genome Biol.
Title	Genome Biology
Publication Year	2000-
ISBN/ISSN	1465-6906
Data from Reference
Alleles (34)
	Ac3^EY10141 BCL7-like^EY00880 BCL7-like^EY10009 CG1832^KG00473 CG8924^EY00245 CG12299^EY01579 Ctet\TeTxLC^TNT.Scer\UAS elav⁵ elav^DmORF elav^ts1 ewg² ewg^elav.NS ewg^elav.PH ewg^G1518 ewg^Scer\UAS.cHa gro¹ gro^C105 Hsap\NRF1^elav.PH Jra^Jbz.Scer\UAS Jra^Scer\UAS.cEa kay^Scer\UAS.cEa Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} N^{dsRNA.P.Scer\UAS} N^Scer\UAS.cMa pan^Scer\UAS.cWa Scer\GAL4^elav.PH Scer\GAL4^{elav.Switch.PO} Scer\GAL4^elav-C155 Scer\GAL4^{Scer\FRT.elav} tkv^{Q199D.Scer\UAS.T:Ivir\HA1} w^+mC wg^{Scer\UAS.cHa.T:Ivir\HA1} wit^A12 wit^B11
Constructs (17)
	P{elav(FRT.ewg)GAL4.eFeG} P{elav(-FRT)GAL4.eFeG} P{elavDmORF} P{elav-NRF-1.H} P{elav-Switch.O} P{ewg^NS} P{Jbz} P{lacW} P{UAS-ewg.H} P{UAS-Fra} P{UAS-Jra} P{UAS-mCD8::GFP.L} P{UAS-N.dsRNA.P} P{UAS-N^full} P{UAS-pan.dTCF} P{UAS-tkv^Q199D} P{UAS-wg.H.T:HA1}
Genes (226)
	All Genes relating to this reference
Insertions (3)
	P{EPgy2}BCL7-like^EY00880 P{GawB}elav^C155 P{lacW}ewg^G1518
Natural transposons (1)
	P-element