Reference Report

Reference
Citation	Weng, M., Golden, K.L., Lee, C.Y. (2010). dFezf/Earmuff Maintains the Restricted Developmental Potential of Intermediate Neural Progenitors in Drosophila. Dev. Cell 18(1): 126--135. (Export to RIS)
FlyBase ID	FBrf0209927
Publication Type	Research paper
PubMed ID	20152183
PubMed Abstract	To ensure normal development and maintenance of homeostasis, the extensive developmental potential of stem cells must be functionally distinguished from the limited developmental potential of transit amplifying cells. Yet the mechanisms that restrict the developmental potential of transit amplifying cells are poorly understood. Here we show that the evolutionarily conserved transcription factor dFezf/Earmuff (Erm) functions cell-autonomously to maintain the restricted developmental potential of the intermediate neural progenitors generated by type II neuroblasts in Drosophila larval brains. Although erm mutant intermediate neural progenitors are correctly specified and show normal apical-basal cortical polarity, they can dedifferentiate back into a neuroblast state, functionally indistinguishable from normal type II neuroblasts. Erm restricts the potential of intermediate neural progenitors by activating Prospero to limit proliferation and by antagonizing Notch signaling to prevent dedifferentiation. We conclude that Erm dependence functionally distinguishes intermediate neural progenitors from neuroblasts in the Drosophila larval brain, balancing neurogenesis with stem cell maintenance.
DOI	10.1016/j.devcel.2009.12.007
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Cell
Title	Developmental Cell
Publication Year	2001-
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Data from Reference
Aberrations (1)
	Df(2L)erm²
Alleles (15)
	Dcr-2^Scer\UAS.cDa erm¹ erm^{Scer\UAS.T:Ivir\HA1} Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Mmus\Fezf1^{Scer\UAS.T:Ivir\HA1} Mmus\Fezf2^{Scer\UAS.T:Ivir\HA1} N^GD14477 N^{intra.GS.Scer\UAS} pros¹⁷ pros^L.Scer\UAS Scer\GAL4^ase.neuro Scer\GAL4^elav-C155 Scer\GAL4^GMR9D11 Scer\GAL4^repo Scer\GAL4^wor.PA
Constructs (11)
	P{ase-GAL4} P{GD14477} P{GMR9D11-GAL4} P{UAS-Dcr-2.D} P{UAS-erm.HA} P{UAS-Fezf1.HA} P{UAS-Fezf2.HA} P{UAS-mCD8::GFP.L} P{UAS-N.intra.GS} P{UAS-pros.L} P{wor.GAL4.A}
Genes (15)
	aPKC ase Dcr-2 dpn erm mira Mmus\Cd8a Mmus\Fezf1 Mmus\Fezf2 N numb pros Scer\GAL4 T:Ivir\HA1 T:Ivir\haemagglutinin
Insertions (2)
	P{GAL4}repo P{GawB}elav^C155
Natural transposons (1)
	P-element