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| Citation | Zhang, Y., Oliver, B. (2010). An evolutionary consequence of dosage compensation on Drosophila melanogaster female X-chromatin structure? BMC Genomics 11(): 6. (Export to RIS) | ||
| FlyBase ID | FBrf0209958 | ||
| Publication Type | Research paper | ||
| PubMed ID | 20051121 | ||
| PubMed Abstract | X chromosomes are subject to dosage compensation in Drosophila males. Dosage compensation requires cis sequence features of the X chromosome that are present in both sexes by definition and trans acting factors that target chromatin modifying machinery to the X specifically in males. The evolution of this system could result in neutral X chromatin changes that will be apparent in females.We find that the general chromatin structure of female X chromosomes is distinct from autosomes. Additionally, specific histone marks associated with dosage compensation and active chromatin marks on the male X chromosome are also enriched on the X chromosomes of females, albeit to a lesser degree.Our data indicate that X chromatin structure is fundamentally different from autosome structure in both sexes. We suggest that the differences between the X chromosomes and autosomes in females are a consequence of mechanisms that have evolved to ensure sufficient X chromosome expression in the soma of males. | ||
| DOI | 10.1186/1471-2164-11-6 | ||
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| Language of Publication | English | ||
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| Publication Type | Journal | ||
| Abbreviation | BMC Genomics | ||
| Title | BMC Genomics | ||
| Publication Year | 2001- | ||
| ISBN/ISSN | 1471-2164 | ||
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Data from Reference
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