Reference Report

Reference
Citation	Cordero, J.B., Cagan, R.L. (2010). Canonical wingless signaling regulates cone cell specification in the Drosophila retina. Dev. Dyn. 239(3): 875--884. (Export to RIS)
FlyBase ID	FBrf0210104
Publication Type	Research paper
PubMed ID	20140910
PubMed Abstract	Correct tissue patterning during development involves multiple morphogenetic events that include specification of different cell fates, cell proliferation, cell death, and coordinated changes in cell shape, position, and adhesion. Here, we use the Drosophila retina to explore the molecular mechanisms that regulate and integrate these various events. In a previous report, we found that wingless (wg) was required to induce a previously unknown surge of cell death ("early death") in the pupal retina. Here, we show that wg is also required to induce the more widely studied mid-pupal cell death ("late death") in a process that involves regulation of DIAP1. Furthermore, our data suggest that wg has a previously unreported role in specifying the glial-like cone cells. This activity requires canonical Wg signaling and is linked with Notch pathway activity. Our work broadens the role of canonical Wg signaling to encompass multiple patterning steps in the emerging Drosophila retina.
DOI	10.1002/dvdy.22235
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Dyn.
Title	Developmental Dynamics
Publication Year	1992-
ISBN/ISSN	1058-8388
Data from Reference
Alleles (17)
	Avic\GFP^Scer\UAS.cUa Ecol\lacZ^sv.SME Ecol\lacZ^th-j5C8 fz2^C1 fz¹⁵ N^GD144 N^spl-1 pan^ΔN.Scer\UAS pygo^S123 Scer\GAL4^GMR.PU Scer\GAL4^sev.PU Scer\GAL4^sv.PJ wg^GD5007 wg^l-12 wg^l-13 wg^l-15 wg^l-17
Constructs (8)
	P{GD144} P{GD5007} P{GMR-GAL4.U} P{sev-GAL4.U} P{spa-GAL4.J} P{sv-lacZ.SME} P{UAS-GFP.U} P{UAS-pan.dTCFΔN}
Genes (15)
	arm Avic\GFP ct Ecol\lacZ elav fz fz2 N pan pros pygo Scer\GAL4 sv th wg
Insertions (1)
	P{lacW}th^j5C8
Natural transposons (1)
	P-element