Open Close
Reference
Citation
Cordero, J.B., Cagan, R.L. (2010). Canonical wingless signaling regulates cone cell specification in the Drosophila retina.  Dev. Dyn. 239(3): 875--884.
FlyBase ID
FBrf0210104
Publication Type
Research paper
Abstract

Correct tissue patterning during development involves multiple morphogenetic events that include specification of different cell fates, cell proliferation, cell death, and coordinated changes in cell shape, position, and adhesion. Here, we use the Drosophila retina to explore the molecular mechanisms that regulate and integrate these various events. In a previous report, we found that wingless (wg) was required to induce a previously unknown surge of cell death ("early death") in the pupal retina. Here, we show that wg is also required to induce the more widely studied mid-pupal cell death ("late death") in a process that involves regulation of DIAP1. Furthermore, our data suggest that wg has a previously unreported role in specifying the glial-like cone cells. This activity requires canonical Wg signaling and is linked with Notch pathway activity. Our work broadens the role of canonical Wg signaling to encompass multiple patterning steps in the emerging Drosophila retina.

PubMed ID
PubMed Central ID
PMC2892184 (PMC) (EuropePMC)
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Dev. Dyn.
    Title
    Developmental Dynamics
    Publication Year
    1992-
    ISBN/ISSN
    1058-8388
    Data From Reference
    Alleles (17)
    Genes (16)
    Natural transposons (1)
    Insertions (1)
    Experimental Tools (1)
    Transgenic Constructs (8)