Reference Report

Reference
Citation	Elsaesser, R., Kalra, D., Li, R., Montell, C. (2010). Light-induced translocation of Drosophila visual Arrestin2 depends on Rac2. Proc. Natl. Acad. Sci. U.S.A. 107(10): 4740--4745. (Export to RIS)
FlyBase ID	FBrf0210213
Publication Type	Research paper
PubMed ID	20176938
PubMed Abstract	Photoreceptor cells are remarkable in their ability to adjust their sensitivity to light over a wide range of intensities. Rapid termination of the photoresponse is achieved in part by shuttling proteins in and out of the light-transducing compartment of the photoreceptor cells. One protein that undergoes light-dependent translocation is the rhodopsin regulatory protein arrestin. However, the mechanisms coupling rhodopsin to arrestin movement are poorly understood. Here we show that light-dependent shuttling of the major arrestin in Drosophila photoreceptor cells, Arrestin2 (Arr2), occurs independently of known elements of the phototransduction cascade. Disruptions of the trimeric G protein, phospholipase Cbeta, the TRP channel, or the Na(+)/Ca(2+) exchanger did not influence Arr2 localization. Rather, we found that loss of the small GTPase Rac2 severely impaired Arr2 movement and prolonged the termination of the photoresponse. Our findings demonstrate that light-induced translocation of Arr2 occurs through a noncanonical rhodopsin/Rac2 pathway, which is distinct from the classical phototransduction cascade.
DOI	10.1073/pnas.0906386107
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Proc. Natl. Acad. Sci. U.S.A.
Title	Proceedings of the National Academy of Sciences of the United States of America
Publication Year	1915-
ISBN/ISSN	0027-8424
Data from Reference
Aberrations (2)
	Df(2R)vg135 Df(3L)pbl-X1
Alleles (25)
	Calx^A Calx^ninaE.PW Cdc42^F89.Scer\UAS Gαq¹ inaC² Mtl^Δ ninaE⁸ ninaE⁹ norpA³⁶ Rac1^N17.Scer\UAS Rac1^V12.Scer\UAS Rac2^Scer\UAS.cEa Rac2^{Scer\UAS.T:Hsap\MYC} Rac2^Δ Rho1^N19.Scer\UAS Rho1^V14.Scer\UAS Scer\FLP1^hs.PG Scer\GAL4^GMR.PF Scer\GAL4^hs.PB Scer\GAL4^ninaE.PT Scer\GAL80^ts.αTub84B sna^Sco trp³ trp⁹ trpl³⁰²
Constructs (13)
	P{GAL4-Hsp70.PB} P{GAL4-ninaE.GMR} P{hsFLP} P{ninaE-Calx.W} P{rh1-GAL4} P{tubP-GAL80^ts} P{UAS-Cdc42.F89} P{UAS-Rac1.N17} P{UAS-Rac1.V12} P{UAS-Rac2.E} P{UAS-Rac2.myc} P{UAS-Rho1.N19} P{UAS-Rho1.V14}
Genes (18)
	Arr2 Calx Cdc42 Gαq inaC Mtl ninaE norpA Rac1 Rac2 Rho1 Scer\FLP1 Scer\GAL4 Scer\GAL80 sna T:Hsap\MYC trp trpl
Insertions (1)
	P{neoFRT}82B
Natural transposons (1)
	P-element