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| Citation | Lee, M.C., Toh, L.L., Yaw, L.P., Luo, Y. (2010). Drosophila octamer elements and pdm-1 dictate the coordinated transcription of core histone genes. J. Biol. Chem. 285(12): 9041--9053. (Export to RIS) | ||
| FlyBase ID | FBrf0210215 | ||
| Publication Type | Research paper | ||
| PubMed ID | 20097756 | ||
| PubMed Abstract | We reveal a set of divergent octamer elements in Drosophila melanogaster (dm) core histone gene promoters. These elements recruit transcription factor POU-domain protein in D. melanogaster 1 (Pdm-1), which along with co-activator dmOct-1 coactivator in S-phase (dmOCA-S), activates transcription from at least the Drosophila histone 2B (dmH2B) and 4 (dmH4) promoters in a fashion similar to the transcription of mammalian histone 2B (H2B) gene activated by octamer binding transcription factor 1 (Oct-1) and Oct-1 coactivator in S-phase (OCA-S). The expression of core histone genes in both kingdoms is coordinated; however, although the expression of mammalian histone genes involves subtype-specific transcription factors and/or co-activator(s), the expression of Drosophila core histone genes is regulated by a common module (Pdm-1/dmOCA-S) in a directly coordinated manner. Finally, dmOCA-S is recruited to the Drosophila histone locus bodies in the S-phase, marking S-phase-specific transcription activation of core histone genes. | ||
| DOI | 10.1074/jbc.M109.075358 | ||
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| Language of Publication | English | ||
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| Publication Type | Journal | ||
| Abbreviation | J. Biol. Chem. | ||
| Title | Journal of Biological Chemistry | ||
| Publication Year | 1905- | ||
| ISBN/ISSN | 0021-9258 | ||
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Data from Reference
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| Genes (8)
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