Open Close
Reference
Citation
Reveal, B., Yan, N., Snee, M.J., Pai, C.I., Gim, Y., Macdonald, P.M. (2010). BREs Mediate Both Repression and Activation of oskar mRNA Translation and Act In trans.  Dev. Cell 18(3): 496--502.
FlyBase ID
FBrf0210218
Publication Type
Research paper
Abstract

Asymmetric positioning of proteins within cells is crucial for cell polarization and function. Deployment of Oskar protein at the posterior pole of the Drosophila oocyte relies on localization of the oskar mRNA, repression of its translation prior to localization, and finally activation of translation. Translational repression is mediated by BREs, regulatory elements positioned in two clusters near both ends of the oskar mRNA 3' UTR. Here we show that some BREs are bifunctional: both clusters of BREs contribute to translational repression, and the 3' cluster has an additional role in release from BRE-dependent repression. Remarkably, both BRE functions can be provided in trans by an oskar mRNA with wild-type BREs that is itself unable to encode Oskar protein. Regulation in trans is likely enabled by assembly of oskar transcripts in cytoplasmic RNPs. Concentration of transcripts in such RNPs is common, and trans regulation of mRNAs may therefore be widespread.

PubMed ID
PubMed Central ID
PMC2841435 (PMC) (EuropePMC)
Related Publication(s)
Note

trans Regulation: Do mRNAs Have a Herd Mentality?
Wilusz and Wilusz, 2010, Dev. Cell 18(3): 333--334 [FBrf0210234]

Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Dev. Cell
    Title
    Developmental Cell
    Publication Year
    2001-
    ISBN/ISSN
    1534-5807 1878-1551
    Data From Reference
    Aberrations (2)
    Alleles (15)
    Genes (9)
    Natural transposons (1)
    Insertions (2)
    Experimental Tools (2)
    Transgenic Constructs (9)