Reference Report

Reference
Citation	Schnorrer, F., Schönbauer, C., Langer, C.C., Dietzl, G., Novatchkova, M., Schernhuber, K., Fellner, M., Azaryan, A., Radolf, M., Stark, A., Keleman, K., Dickson, B.J. (2010). Systematic genetic analysis of muscle morphogenesis and function in Drosophila. Nature 464(7286): 287--291. (Export to RIS)
FlyBase ID	FBrf0210226
Publication Type	Research paper
PubMed ID	20220848
PubMed Abstract	Systematic genetic approaches have provided deep insight into the molecular and cellular mechanisms that operate in simple unicellular organisms. For multicellular organisms, however, the pleiotropy of gene function has largely restricted such approaches to the study of early embryogenesis. With the availability of genome-wide transgenic RNA interference (RNAi) libraries in Drosophila, it is now possible to perform a systematic genetic dissection of any cell or tissue type at any stage of the lifespan. Here we apply these methods to define the genetic basis for formation and function of the Drosophila muscle. We identify a role in muscle for 2,785 genes, many of which we assign to specific functions in the organization of muscles, myofibrils or sarcomeres. Many of these genes are phylogenetically conserved, including genes implicated in mammalian sarcomere organization and human muscle diseases.
DOI	10.1038/nature08799
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Nature
Title	Nature
Publication Year	1869-
ISBN/ISSN	0028-0836
Data from Reference
Alleles (21)
	Actn^GD1354 Avic\GFP^{Zasp66-ZCL0663} Bsg^GD15718 bt^GD14482 CG5800^GD11773 CG8578^GD13973 CG13366^GD14994 CG14260^GD8276 cora^GD1405 coro^GD14217 fliI³ fliI⁴ fliI^GD1446 fln^GD10601 flr^GD12603 His2A^GD15048 how^GD1462 hts^GD14187 rhea^GD12050 Scer\GAL4^Mef2.PR Unc-89^GD14839
Constructs (18)
	P{GAL4-Mef2.R} P{GD1354} P{GD1405} P{GD1446} P{GD1462} P{GD8276} P{GD10601} P{GD11773} P{GD12050} P{GD12603} P{GD13973} P{GD14187} P{GD14217} P{GD14482} P{GD14839} P{GD14994} P{GD15048} P{GD15718}
Genes (32)
	Actn AnxB11 Avic\GFP Bsg bt CG5800 CG8578 CG13366 CG14260 cora coro eag fliI fln flr His2A how htl hts Ilk Mhc Mical park Pdp1 rhea Scer\GAL4 sls Tm2 TpnC47D TpnC73F Unc-89 Zasp66
Insertions (1)
	P{PTT-GA}Zasp66^ZCL0663
Natural transposons (1)
	P-element