Reference Report

Reference
Citation	Ayyar, S., Pistillo, D., Calleja, M., Brookfield, A., Gittins, K., Goldstone, C., Simpson, P. (2007). NF-kappaB/Rel-mediated regulation of the neural fate in Drosophila. PLoS ONE 2(11): e1178. (Export to RIS)
FlyBase ID	FBrf0210269
Publication Type	Research paper
PubMed ID	18000549
PubMed Abstract	Two distinct roles are described for Dorsal, Dif and Relish, the three NF-kappaB/Rel proteins of Drosophila, in the development of the peripheral nervous system. First, these factors regulate transcription of scute during the singling out of sensory organ precursors from clusters of cells expressing the proneural genes achaete and scute. This effect is possibly mediated through binding sites for NF-kappaB/Rel proteins in a regulatory module of the scute gene required for maintenance of scute expression in precursors as well as repression in cells surrounding precursors. Second, genetic evidence suggests that the receptor Toll-8, Relish, Dif and Dorsal, and the caspase Dredd pathway are active over the entire imaginal disc epithelium, but Toll-8 expression is excluded from sensory organ precursors. Relish promotes rapid turnover of transcripts of the target genes scute and asense through an indirect, post-transcriptional mechanism. We propose that this buffering of gene expression levels serves to keep the neuro-epithelium constantly poised for neurogenesis.
DOI	10.1371/journal.pone.0001178
Related Publication(s)
Supplementary material	Figure S1. [FBrf0211173]
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Language of Publication	English
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Publication Type	Journal
Abbreviation	PLoS ONE
Title	PLoS ONE
Publication Year	2006-
ISBN/ISSN	1932-6203
Data from Reference
Aberrations (1)
	Df(2L)TW119
Alleles (23)
	ac^Scer\UAS.cUa ase^Scer\UAS.cAa Dif¹ Dif^LA00958 dl¹ dl⁴ dl^UY2278 Dredd^EP1412 E(spl)m7-HLH^{Act.Scer\UAS.T:Hsim\VP16} E(spl)m8-HLH^Scer\UAS.cUa Ecol\lacZ^neur-A101 Ecol\lacZ^sc.SRV.α3 Ecol\lacZ^sc.SRV Rel^E20 Rel^{Scer\UAS.T:Ivir\HA1,T:Hsim\VP16} Rel^{Scer\UAS.T:Ivir\HA1} sc^Hw-Ua sc^Scer\UAS.cUa Scer\GAL4^Bx-MS1096 Scer\GAL4^{neur-GAL4-A101} Scer\GAL4^sca-537.4 Scer\GAL4^Tollo-MD806 Tollo¹
Constructs (10)
	P{GawB} P{m7^Act} P{sc-lacZ.SRV} P{sc-lacZ.α3} P{UAS-ac.U} P{UAS-ase.A} P{UAS-E(spl).U} P{UAS-Rel.HA} P{UAS-Rel.HA-VP16} P{UAS-sc.U}
Genes (18)
	ac ase cact Dif dl Dredd E(spl)m7-HLH E(spl)m8-HLH Ecol\lacZ neur peb Rel sc Scer\GAL4 sens T:Hsim\VP16 T:Ivir\HA1 Tollo
Insertions (8)
	copia{}sc^Hw-Ua P{GawB}Bx^MS1096 P{GawB}MD806 P{GawB}neur^GAL4-A101 P{GawB}sca^537.4 P{lArB}neur^A101 P{Mae-UAS.6.11}Dif^LA00958 P{Mae-UAS.6.11}dl^UY2278