Reference Report

Reference
Citation	Suh, J.M., Stenesen, D., Peters, J.M., Inoue, A., Cade, A., Graff, J.M. (2008). An RGS-containing sorting nexin controls Drosophila lifespan. PLoS ONE 3(5): e2152. (Export to RIS)
FlyBase ID	FBrf0210283
Publication Type	Research paper
PubMed ID	18478054
PubMed Abstract	The pursuit of eternal youth has existed for centuries and recent data indicate that fat-storing tissues control lifespan. In a D. melanogaster fat body insertional mutagenic enhancer trap screen designed to isolate genes that control longevity, we identified a regulator of G protein signaling (RGS) domain containing sorting nexin, termed snazarus (sorting nexin lazarus, snz). Flies with insertions into the 5' UTR of snz live up to twice as long as controls. Transgenic expression of UAS-Snz from the snz Gal4 enhancer trap insertion, active in fat metabolic tissues, rescued lifespan extension. Further, the lifespan extension of snz mutants was independent of endosymbiont, e.g., Wolbachia, effects. Notably, old snz mutant flies remain active and fertile indicating that snz mutants have prolonged youthfulness, a goal of aging research. Since mammals have snz-related genes, it is possible that the functions of the snz family may be conserved to humans.
DOI	10.1371/journal.pone.0002152
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Language of Publication	English
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Publication Type	Journal
Abbreviation	PLoS ONE
Title	PLoS ONE
Publication Year	2006-
ISBN/ISSN	1932-6203
Data from Reference
Alleles (10)
	Avic\GFP^{E.Scer\UAS.cMa} mth¹ Scer\GAL4^DcG Scer\GAL4^snz-C32 Scer\GAL4^wB snz^5-SZ-4089 snz^C32 snz^C32-rv1 snz^GG01409 snz^Scer\UAS.cSa
Constructs (3)
	P{GawB} P{UAS-EGFP.M} P{UAS-snz.S}
Genes (4)
	Avic\GFP mth Scer\GAL4 snz
Insertions (4)
	P{GAL4}DcG P{GawB}snz^C32 P{Mae-UAS.6.11}snz^GG01409 P{RS5}snz^5-SZ-4089
Natural transposons (1)
	P-element