Reference Report

Reference
Citation	Spierer, A., Begeot, F., Spierer, P., Delattre, M. (2008). SU(VAR)3-7 links heterochromatin and dosage compensation in Drosophila. PLoS Genet. 4(5): e1000066. (Export to RIS)
FlyBase ID	FBrf0210330
Publication Type	Research paper
PubMed ID	18451980
PubMed Abstract	In Drosophila, dosage compensation augments X chromosome-linked transcription in males relative to females. This process is achieved by the Dosage Compensation Complex (DCC), which associates specifically with the male X chromosome. We previously found that the morphology of this chromosome is sensitive to the amounts of the heterochromatin-associated protein SU(VAR)3-7. In this study, we examine the impact of change in levels of SU(VAR)3-7 on dosage compensation. We first demonstrate that the DCC makes the X chromosome a preferential target for heterochromatic markers. In addition, reduced or increased amounts of SU(VAR)3-7 result in redistribution of the DCC proteins MSL1 and MSL2, and of Histone 4 acetylation of lysine 16, indicating that a wild-type dose of SU(VAR)3-7 is required for X-restricted DCC targeting. SU(VAR)3-7 is also involved in the dosage compensated expression of the X-linked white gene. Finally, we show that absence of maternally provided SU(VAR)3-7 renders dosage compensation toxic in males, and that global amounts of heterochromatin affect viability of ectopic MSL2-expressing females. Taken together, these results bring to light a link between heterochromatin and dosage compensation.
DOI	10.1371/journal.pgen.1000066
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Language of Publication	English
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Publication Type	Journal
Abbreviation	PLoS Genet.
Title	PLoS Genetics
Publication Year	2005-
ISBN/ISSN	1553-7404 1553-7390
Data from Reference
Aberrations (1)
	Dp(3;3)Su(var)3-7⁹
Alleles (6)
	mle¹ msl-1^Hsp83.PC msl-2^Hsp83.PK roX1^t4.9 Su(var)3-7^{FL.hs.T:Ivir\HA1} Su(var)3-7^R2a8
Constructs (4)
	P{GMroX1} P{H83M2} P{Hsp83-msl-1.C} P{hs-Su(var)3-7.FL}
Genes (9)
	mle mof msl-1 msl-2 msl-3 roX1 roX2 Su(var)3-7 w