Reference Report

Reference
Citation	Kong, E.C., Woo, K., Li, H., Lebestky, T., Mayer, N., Sniffen, M.R., Heberlein, U., Bainton, R.J., Hirsh, J., Wolf, F.W. (2010). A pair of dopamine neurons target the D1-like dopamine receptor DopR in the central complex to promote ethanol-stimulated locomotion in Drosophila. PLoS ONE 5(4): e9954. (Export to RIS)
FlyBase ID	FBrf0210514
Publication Type	Research paper
PubMed ID	20376353
PubMed Abstract	Dopamine is a mediator of the stimulant properties of drugs of abuse, including ethanol, in mammals and in the fruit fly Drosophila. The neural substrates for the stimulant actions of ethanol in flies are not known. We show that a subset of dopamine neurons and their targets, through the action of the D1-like dopamine receptor DopR, promote locomotor activation in response to acute ethanol exposure. A bilateral pair of dopaminergic neurons in the fly brain mediates the enhanced locomotor activity induced by ethanol exposure, and promotes locomotion when directly activated. These neurons project to the central complex ellipsoid body, a structure implicated in regulating motor behaviors. Ellipsoid body neurons are required for ethanol-induced locomotor activity and they express DopR. Elimination of DopR blunts the locomotor activating effects of ethanol, and this behavior can be restored by selective expression of DopR in the ellipsoid body. These data tie the activity of defined dopamine neurons to D1-like DopR-expressing neurons to form a neural circuit that governs acute responding to ethanol.
DOI	10.1371/journal.pone.0009954
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Language of Publication	English
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Publication Type	Journal
Abbreviation	PLoS ONE
Title	PLoS ONE
Publication Year	2006-
ISBN/ISSN	1932-6203
Data from Reference
Aberrations (2)
	Df(3R)ED5634 In(3LR)234
Alleles (43)
	Ctet\TeTxLC^{IMPTNT.Scer\UAS} Ctet\TeTxLC^TNT.Scer\UAS DAT^fmn DAT^Scer\UAS.cKa Ddc^{HL7.T:Scer\GAL4} DopR^f02676 DopR^PL00420 DopR^Scer\UAS.cKa Hsap\ZDHHC17^{Scer\UAS.T:Avic\GFP} n-syb^{Scer\UAS.T:Avic\GFP-EGFP} Scer\GAL4^2.70 Scer\GAL4^3.16 Scer\GAL4^4-67 Scer\GAL4^4.13 Scer\GAL4^4.69 Scer\GAL4^5.21 Scer\GAL4^5.30 Scer\GAL4^5.36 Scer\GAL4^6.61 Scer\GAL4^11.17 Scer\GAL4^11.32 Scer\GAL4^11.33 Scer\GAL4^11.113 Scer\GAL4^11.148 Scer\GAL4^11.243 Scer\GAL4^12.30 Scer\GAL4^17d Scer\GAL4^078Y Scer\GAL4^Aph-4-c232 Scer\GAL4^c42 Scer\GAL4^c107 Scer\GAL4^c346 Scer\GAL4^c547 Scer\GAL4^c561 Scer\GAL4^c819 Scer\GAL4^Ddc.HL5 Scer\GAL4^lilli-189Y Scer\GAL4^ple.PF Scer\GAL4^smid-C161 Scer\GAL4^Tab2-201Y Scer\GAL4^tub.PU Scer\GAL80^ple.PK TrpA1^Scer\UAS.cKa
Constructs (14)
	P{Ddc-GAL4.HL5} P{Ddc-GAL4.HL7} P{GAL4.4-67} P{GawB} P{ple-GAL4.F} P{ple-GAL80} P{tub-GAL4.U} P{UAS(-FRT)TeTxLC.IMPTNT} P{UAS-DAT.K} P{UAS-DopR.K} P{UAS-hHIP14.GFP} P{UAS-n-syb.eGFP} P{UAS-TeTxLC.tnt} P{UAS-TrpA1.K}
Genes (11)
	Ctet\TeTxLC DAT Ddc DopR Hsap\ZDHHC17 n-syb ple Scer\GAL4 Scer\GAL80 T:Scer\GAL4 TrpA1
Insertions (29)
	P{GAL4}17d P{GAL4}c547 P{GAL4}dpr8^c561 P{GawB}2.70 P{GawB}3.16 P{GawB}4.13 P{GawB}4.69 P{GawB}5.21 P{GawB}5.30 P{GawB}5.36 P{GawB}6.61 P{GawB}11.17 P{GawB}11.32 P{GawB}11.33 P{GawB}11.113 P{GawB}11.148 P{GawB}11.243 P{GawB}12.30 P{GawB}078Y P{GawB}Aph-4^c232 P{GawB}c42 P{GawB}c107 P{GawB}c346 P{GawB}c819 P{GawB}lilli^189Y P{GawB}smid^C161 P{GawB}Tab2^201Y PBac{GAL4D,EYFP}DopR^PL00420 PBac{WH}DopR^f02676
Natural transposons (1)
	P-element