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Chamilos, G., Bignell, E.M., Schrettl, M., Lewis, R.E., Leventakos, K., May, G.S., Haas, H., Kontoyiannis, D.P. (2010). Exploring the concordance of Aspergillus fumigatus pathogenicity in mice and Toll-deficient flies.  Med. Mycol. 48(3): 506--510.
FlyBase ID
FBrf0210525
Publication Type
Research paper
Abstract
The pathogenicity of six mutants of Aspergillus fumigatus that had been previously characterized in mice was assessed in Toll-deficient Drosophila melanogaster flies. Four out of six mutants of A. fumigatus, which displayed attenuated virulence in mice due to defects in siderophore biosynthesis (DeltasidA, DeltasidD), PABA metabolism (H515), and starvation stress response (DeltacpcA), also had attenuated virulence in the fly model. In addition, similarly to previous findings in the mouse model, DeltasidG mutant that is defective in extracellular siderophore biosynthesis retained full virulence in Toll-deficient flies. Overall, our studies reveal a high level of concordance between fly and murine models of invasive aspergillosis.
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Med. Mycol.
    Title
    Medical Mycology
    Publication Year
    1998-
    ISBN/ISSN
    1369-3786 1460-2709
    Data From Reference
    Genes (1)
    Human Disease Models (2)