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Citation
Neisch, A.L., Speck, O., Stronach, B., Fehon, R.G. (2010). Rho1 regulates apoptosis via activation of the JNK signaling pathway at the plasma membrane.  J. Cell Biol. 189(2): 311--323.
FlyBase ID
FBrf0210554
Publication Type
Research paper
Abstract

Precisely controlled growth and morphogenesis of developing epithelial tissues require coordination of multiple factors, including proliferation, adhesion, cell shape, and apoptosis. RhoA, a small GTPase, is known to control epithelial morphogenesis and integrity through its ability to regulate the cytoskeleton. In this study, we examine a less well-characterized RhoA function in cell survival. We demonstrate that the Drosophila melanogaster RhoA, Rho1, promotes apoptosis independently of Rho kinase through its effects on c-Jun NH(2)-terminal kinase (JNK) signaling. In addition, Rho1 forms a complex with Slipper (Slpr), an upstream activator of the JNK pathway. Loss of Moesin (Moe), an upstream regulator of Rho1 activity, results in increased levels of Rho1 at the plasma membrane and cortical accumulation of Slpr. Together, these results suggest that Rho1 functions at the cell cortex to regulate JNK activity and implicate Rho1 and Moe in epithelial cell survival.

PubMed ID
PubMed Central ID
PMC2856900 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    J. Cell Biol.
    Title
    Journal of Cell Biology
    Publication Year
    1966-
    ISBN/ISSN
    0021-9525
    Data From Reference
    Alleles (37)
    Genes (28)
    Physical Interactions (6)
    Cell Lines (1)
    Natural transposons (1)
    Insertions (9)
    Experimental Tools (3)
    Transgenic Constructs (26)