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Citation
Quinones, G.A., Jin, J., Oro, A.E. (2010). I-BAR protein antagonism of endocytosis mediates directional sensing during guided cell migration.  J. Cell Biol. 189(2): 353--367.
FlyBase ID
FBrf0210570
Publication Type
Research paper
Abstract

Although directed cellular migration facilitates the coordinated movement of cells during development and repair, the mechanisms regulating such migration remain poorly understood. Missing-in-metastasis (MIM) is a defining member of the inverse Bin/Amphiphysin/Rvs domain (I-BAR) subfamily of lipid binding, cytoskeletal regulators whose levels are altered in a number of cancers. Here, we provide the first genetic evidence that an I-BAR protein regulates directed cell migration in vivo. Drosophila MIM (dmim) is involved in Drosophila border cell migration, with loss of dmim function resulting in a lack of directional movement by the border cell cluster. In vivo endocytosis assays combined with genetic analyses demonstrate that the dmim product regulates directed cell movement by inhibiting endocytosis and antagonizing the activities of the CD2-associated protein/cortactin complex in these cells. These studies demonstrate that DMIM antagonizes pro-endocytic components to facilitate polarity and localized guidance cue sensing during directional cell migration.

PubMed ID
PubMed Central ID
PMC2856902 (PMC) (EuropePMC)
Related Publication(s)
Note

Cell migration: MIM takes the driver's seat.
Van de Bor and Noselli, 2010, Curr. Biol. 20(14): R606--R608 [FBrf0214149]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    J. Cell Biol.
    Title
    Journal of Cell Biology
    Publication Year
    1966-
    ISBN/ISSN
    0021-9525
    Data From Reference
    Alleles (10)
    Genes (17)
    Physical Interactions (2)
    Cell Lines (1)
    Natural transposons (1)
    Insertions (2)
    Experimental Tools (4)
    Transgenic Constructs (6)