Reference Report

Reference
Citation	Hahn, K., Miranda, M., Francis, V.A., Vendrell, J., Zorzano, A., Teleman, A.A. (2010). PP2A regulatory subunit PP2A-B' counteracts S6K phosphorylation. Cell Metab. 11(5): 438--444. (Export to RIS)
FlyBase ID	FBrf0210726
Publication Type	Research paper
PubMed ID	20444422
PubMed Abstract	The insulin/TOR signaling pathway plays a crucial role in animal homeostasis, sensing nutrient status to regulate organismal growth and metabolism. We identify here the Drosophila B' regulatory subunit of PP2A (PP2A-B') as a novel, conserved component of the insulin pathway that specifically targets the PP2A holoenzyme to dephosphorylate S6K. PP2A-B' knockout flies have elevated S6K phosphorylation and exhibit phenotypes typical of elevated insulin signaling such as reduced total body triglycerides and reduced longevity. We show that PP2A-B' interacts with S6K both physically and genetically. The human homolog of PP2A-B', PPP2R5C, also counteracts S6K1 phosphorylation, indicating a conserved mechanism in mammals. Since S6K affects development of cancer and metabolic disease, our data identify PPP2R5C as a novel factor of potential medical relevance.
DOI	10.1016/j.cmet.2010.03.015
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Cell Metab.
Title	Cell Metabolism
Publication Year	2005-
ISBN/ISSN	1550-4131
Data from Reference
Alleles (7)
	PP2A-B'^KO1 PP2A-B'^KO2 PP2A-B'^{Scer\UAS.T:Zzzz\FLAG} S6k⁰⁷⁰⁸⁴ Scer\GAL4^en.PU Scer\GAL4^ey.PH Scer\GAL4^hs.PB
Constructs (4)
	P{en-GAL4.U} P{GAL4-ey.H} P{GAL4-Hsp70.PB} P{UAS-PP2A-B'.FLAG}
Genes (6)
	Ilp2 Ilp5 PP2A-B' S6k Scer\GAL4 T:Zzzz\FLAG
Natural transposons (1)
	P-element