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Citation
Li, B., Gordon, G.M., Du, C.H., Xu, J., Du, W. (2010). Specific Killing of Rb Mutant Cancer Cells by Inactivating TSC2.  Cancer Cell 17(5): 469--480.
FlyBase ID
FBrf0210758
Publication Type
Research paper
Abstract

The retinoblastoma (Rb) tumor suppressor is often inactivated in cancers. To identify genes that can be used to specifically target such cancers, we carried out a genetic screen in Drosophila. We identified gig (fly TSC2) and found that inactivation of rbf (fly Rb) and gig synergistically induced cell death. Interestingly, inactivation of TSC2 specifically kills Rb mutant cancer cells under stress conditions, which is correlated with an inhibition of tumor growth. We show that cancer cell killing induced by concomitant inactivation of Rb and TSC2 is mediated by increased cellular stress, including oxidative stress. Inactivation of TSC2 and Rb synergistically induce oxidative stress via increased protein synthesis, inhibited de novo lipid synthesis, and decreased reactive oxygen species scavenger enzyme SOD2 induction.

PubMed ID
PubMed Central ID
PMC2873973 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cancer Cell
    Title
    Cancer Cell
    ISBN/ISSN
    1535-6108 1878-3686
    Data From Reference
    Alleles (8)
    Genes (8)