Reference Report

Reference
Citation	Renault, A.D., Kunwar, P.S., Lehmann, R. (2010). Lipid phosphate phosphatase activity regulates dispersal and bilateral sorting of embryonic germ cells in Drosophila. Development 137(11): 1815--1823. (Export to RIS)
FlyBase ID	FBrf0210764
Publication Type	Research paper
PubMed ID	20431117
PubMed Abstract	In Drosophila, germ cell survival and directionality of migration are controlled by two lipid phosphate phosphatases (LPP), wunen (wun) and wunen-2 (wun2). wun wun2 double mutant analysis reveals that the two genes, hereafter collectively called wunens, act redundantly in primordial germ cells. We find that wunens mediate germ cell-germ cell repulsion and that this repulsion is necessary for germ cell dispersal and proper transepithelial migration at the onset of migration and for the equal sorting of the germ cells between the two embryonic gonads during their migration. We propose that this dispersal function optimizes adult fecundity by assuring maximal germ cell occupancy of both gonads. Furthermore, we find that the requirement for wunens in germ cell survival can be eliminated by blocking germ cell migration. We suggest that this essential function of Wunen is needed to maintain cell integrity in actively migrating germ cells.
DOI	10.1242/dev.046110
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Secondary IDs
Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (3)
	Df(2R)Pu^rP133a Df(2R)w45-19g Df(2R)wun-GL
Alleles (21)
	gcl^A26-10 Moe^{DB.nos.nos3'UTR,T:Avic\GFP-EGFP} Moe^{GMA.Scer\UAS.T:Avic\GFP-S65T} Moe^{nos.T:Disc\RFP} Rac1^N17.Scer\UAS Rac1^V12.Scer\UAS Rho1^N19.Scer\UAS Rho1^Scer\UAS.cMa Rho1^V14.Scer\UAS Scer\GAL4^{nos.UTR.T:Hsim\VP16} Scer\GAL4^twi.PG shg^A9-49 srp² wun2^EP2208ex60 wun2^EP2650ex34 wun2^{H326K.Scer\UAS.T:Hsap\MYC} wun2^N14 wun2^{Scer\UAS.T:Hsap\MYC} wun⁴⁹ wun^EMS9 wun^Scer\UAS.cZa
Constructs (13)
	P{GAL4::VP16-nos.UTR} P{GAL4-twi.G} P{nos-Moe.EGFP.nos3'UTR} P{nos-Moe.RFP} P{UAS-GMA} P{UAS-Rac1.N17} P{UAS-Rac1.V12} P{UAS-Rho1.N19} P{UAS-Rho1.Sph} P{UAS-Rho1.V14} P{UAS-wun2.H326K} P{UAS-wun2.Myc} P{UAS-wun.Z}
Genes (12)
	gcl Moe Rac1 Rho1 Scer\GAL4 shg srp T:Disc\RFP vas wun wun2 α-Spec
Natural transposons (1)
	P-element