Reference Report

Reference
Citation	Scantlebury, N., Zhao, X.L., Rodriguez Moncalvo, V.G., Camiletti, A., Zahanova, S., Dineen, A., Xin, J.H., Campos, A.R. (2010). The Drosophila Gene RanBPM Functions in the Mushroom Body to Regulate Larval Behavior. PLoS ONE 5(5): e10652. (Export to RIS)
FlyBase ID	FBrf0210838
Publication Type	Research paper
PubMed ID	20498842
PubMed Abstract	In vertebrates, Ran-Binding Protein in the Microtubule Organizing Center (RanBPM) appears to function as a scaffolding protein in a variety of signal transduction pathways. In Drosophila, RanBPM is implicated in the regulation of germ line stem cell (GSC) niche organization in the ovary. Here, we addressed the role of RanBPM in nervous system function in the context of Drosophila larval behavior.We report that in Drosophila, RanBPM is required for larval feeding, light-induced changes in locomotion, and viability. RanBPM is highly expressed in the Kenyon cells of the larval mushroom body (MB), a structure well studied for its role in associative learning in Drosophila and other insects. RanBPM mutants do not display major disruption in nervous system morphology besides reduced proliferation. Expression of the RanBPM gene in the Kenyon cells is sufficient to rescue all behavioral phenotypes. Through genetic epistasis experiments, we demonstrate that RanBPM participates with the Drosophila orthologue of the Fragile X Mental Retardation Protein (FMRP) in the development of neuromuscular junction (NMJ).We demonstrate that the RanBPM gene functions in the MB neurons for larval behavior. Our results suggest a role for this gene in an FMRP-dependent process. Taken together our findings point to a novel role for the MB in larval behavior.
DOI	10.1371/journal.pone.0010652
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Language of Publication	English
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Publication Type	Journal
Abbreviation	PLoS ONE
Title	PLoS ONE
Publication Year	2006-
ISBN/ISSN	1932-6203
Data from Reference
Alleles (16)
	Avic\GFP^{Scer\UAS.T:Ecol\lacZ,T:SV40\nls2} Fmr1^EP3517 Fmr1^Δ50M Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} RanBPM^k05201 RanBPM^{long.Scer\UAS} RanBPM^revertant RanBPM^s135 RanBPM^S.Scer\UAS RanBPM^ts7 Scer\GAL4^386Y Scer\GAL4^elav.PLu Scer\GAL4^Mef2.247 Scer\GAL4^Mef2.PR Scer\GAL4^Tab2-201Y Scer\GAL4^αTub84B.PL
Constructs (8)
	P{GAL4-elav.L} P{GAL4-Mef2.R} P{Mef2-GAL4.247} P{tubP-GAL4} P{UAS-GFP::lacZ.nls} P{UAS-mCD8::GFP.L} P{UAS-RanBPM.long} P{UAS-RanBPM.S}
Genes (7)
	Avic\GFP CG12896 Fmr1 His3 Mmus\Cd8a RanBPM Scer\GAL4
Insertions (3)
	P{GawB}386Y P{GawB}Tab2^201Y P{lacW}RanBPM^k05201
Natural transposons (1)
	P-element