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Reference Report
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| Citation | Karam, C.S., Kellner, W.A., Takenaka, N., Clemmons, A.W., Corces, V.G. (2010). 14-3-3 mediates histone cross-talk during transcription elongation in Drosophila. PLoS Genet. 6(6): e1000975. (Export to RIS) | ||
| FlyBase ID | FBrf0210998 | ||
| Publication Type | Research paper | ||
| PubMed ID | 20532201 | ||
| PubMed Abstract | Post-translational modifications of histone proteins modulate the binding of transcription regulators to chromatin. Studies in Drosophila have shown that the phosphorylation of histone H3 at Ser10 (H3S10ph) by JIL-1 is required specifically during early transcription elongation. 14-3-3 proteins bind H3 only when phosphorylated, providing mechanistic insights into the role of H3S10ph in transcription. Findings presented here show that 14-3-3 functions downstream of H3S10ph during transcription elongation. 14-3-3 proteins localize to active genes in a JIL-1-dependent manner. In the absence of 14-3-3, levels of actively elongating RNA polymerase II are severely diminished. 14-3-3 proteins interact with Elongator protein 3 (Elp3), an acetyltransferase that functions during transcription elongation. JIL-1 and 14-3-3 are required for Elp3 binding to chromatin, and in the absence of either protein, levels of H3K9 acetylation are significantly reduced. These results suggest that 14-3-3 proteins mediate cross-talk between histone phosphorylation and acetylation at a critical step in transcription elongation. | ||
| DOI | 10.1371/journal.pgen.1000975 | ||
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| Language of Publication | English | ||
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| Publication Type | Journal | ||
| Abbreviation | PLoS Genet. | ||
| Title | PLoS Genetics | ||
| Publication Year | 2005- | ||
| ISBN/ISSN | 1553-7404 1553-7390 | ||
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Data from Reference
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| Genes (9)
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