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Reference
Citation
Haberman, A.S., Akbar, M.A., Ray, S., Krämer, H. (2010). Drosophila acinus encodes a novel regulator of endocytic and autophagic trafficking.  Development 137(13): 2157--2166.
FlyBase ID
FBrf0211007
Publication Type
Research paper
Abstract

Endosomal trafficking affects many cellular pathways from cell signaling to metabolism, but little is known about how these effects are coordinated. In a genetic screen for mutants affecting endosomal trafficking, we identified Drosophila acinus (dacn; hook-like). Its mammalian homolog Acinus has been implicated in RNA processing and chromatin fragmentation during apoptosis. Loss-of-function analysis of dacn revealed two distinct functions. First, dacn is required for stabilization of early endosomes, thus modulating levels of Notch and Egfr signaling. Second, loss of dacn interferes with cellular starvation responses by inhibiting autophagosome maturation. By contrast, overexpression of dacn causes lethality due to enhanced autophagy. We show that this enhanced autophagy is independent of the Tor pathway. Taken together, our data show that dacn encodes a regulator of endosomal and autophagosomal dynamics, modulating developmental signaling and the cellular response to starvation.

PubMed ID
PubMed Central ID
PMC2882135 (PMC) (EuropePMC)
Related Publication(s)
Note

Acinus: A nuclear regulator of autophagy and endocytic trafficking.
Krämer, 2010, Autophagy 6(7): 974--975 [FBrf0211923]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Development
    Title
    Development
    Publication Year
    1987-
    ISBN/ISSN
    0950-1991
    Data From Reference
    Aberrations (1)
    Alleles (15)
    Genes (19)
    Natural transposons (1)
    Insertions (1)
    Experimental Tools (2)
    Transgenic Constructs (10)