Reference Report

Reference
Citation	Gettings, M., Serman, F., Rousset, R., Bagnerini, P., Almeida, L., Noselli, S. (2010). JNK Signalling Controls Remodelling of the Segment Boundary through Cell Reprogramming during Drosophila Morphogenesis. PLoS Biol. 8(6): e1000390. (Export to RIS)
FlyBase ID	FBrf0211014
Publication Type	Research paper
PubMed ID	20543996
PubMed Abstract	Segments are fundamental units in animal development which are made of distinct cell lineages separated by boundaries. Although boundaries show limited plasticity during their formation for sharpening, cell lineages make compartments that become tightly restricted as development goes on. Here, we characterize a unique case of breaking of the segment boundary in late drosophila embryos. During dorsal closure, specific cells from anterior compartments cross the segment boundary and enter the adjacent posterior compartments. This cell mixing behaviour is driven by an anterior-to-posterior reprogramming mechanism involving de novo expression of the homeodomain protein Engrailed. Mixing is accompanied by stereotyped local cell intercalation, converting the segment boundary into a relaxation compartment important for tension-release during morphogenesis. This process of lineage switching and cell remodelling is controlled by JNK signalling. Our results reveal plasticity of segment boundaries during late morphogenesis and a role for JNK-dependent developmental reprogramming in this process.
DOI	10.1371/journal.pbio.1000390
Related Publication(s)
Note	Mixer Cell formation during dorsal closure: a new developmental model of JNK-dependent natural cell reprogramming in Drosophila. Gettings and Noselli, 2011, Fly 5(4): 327--332 [FBrf0217941]
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Language of Publication	English
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Publication Type	Journal
Abbreviation	PLoS Biol.
Title	PLoS Biology
Publication Year	2003-
ISBN/ISSN	1545-7885 1544-9173
Data from Reference
Alleles (20)
	arm^{+mOa.T:Avic\GFP} arm^{S10.Scer\UAS.T:Hsap\MYC} bsk^DN.Scer\UAS Disc\RFP^{Scer\UAS.T:Myr-Src64B} Ecol\lacZ^puc-E69 en^GD13214 hep¹ hep^Act.Scer\UAS hep^r75 hep^Scer\UAS.cBa hep^unspecified Hsap\ACTB^{Scer\UAS.P\T.T:Avic\GFP-ECFP} Lam^{Scer\UAS.T:Avic\GFP} puc^Scer\UAS.cMa Scer\GAL4^en-e16E Scer\GAL4^ptc-559.1 wg^l-17 wg^Scer\UAS.cLa zip¹ α-Cat^{Scer\UAS.T:Avic\GFP-sg}
Constructs (12)
	P{arm-GFP.P} P{GD13214} P{UAS-arm.S10} P{UAS-bsk.DN} P{UAS-ECFP-β-actin} P{UAS-Hep.Act} P{UAS-hep.B} P{UAS-Lam.GFP} P{UAS-myr-mRFP} P{UAS-puc.M} P{UAS-wg.L} P{UAS-α-Cat.T:GFP.sg}
Genes (15)
	arm bsk Disc\RFP Ecol\lacZ en ena hep Hsap\ACTB Lam ptc puc Scer\GAL4 wg zip α-Cat
Insertions (3)
	P{A92}puc^E69 P{en2.4-GAL4}e16E P{GawB}ptc^559.1
Transcripts (3)
	Ecol\lacZ^puc-E69RA Scer\GAL4^en-e16ERA Scer\GAL4^ptc-559.1RA