Reference Report

Reference
Citation	Hilgers, V., Bushati, N., Cohen, S.M. (2010). Drosophila microRNAs 263a/b Confer Robustness during Development by Protecting Nascent Sense Organs from Apoptosis. PLoS Biol. 8(6): e1000396. (Export to RIS)
FlyBase ID	FBrf0211074
Publication Type	Research paper
PubMed ID	20563308
PubMed Abstract	miR-263a/b are members of a conserved family of microRNAs that are expressed in peripheral sense organs across the animal kingdom. Here we present evidence that miR-263a and miR-263b play a role in protecting Drosophila mechanosensory bristles from apoptosis by down-regulating the pro-apoptotic gene head involution defective. Both microRNAs are expressed in the bristle progenitors, and despite a difference in their seed sequence, they share this key common target. In miR-263a and miR-263b deletion mutants, loss of bristles appears to be sporadic, suggesting that the role of the microRNAs may be to ensure robustness of the patterning process by promoting survival of these functionally specified cells. In the context of the retina, this mechanism ensures that the interommatidial bristles are protected during the developmentally programmed wave of cell death that prunes excess cells in order to refine the pattern of the pupal retina.
DOI	10.1371/journal.pbio.1000396
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Language of Publication	English
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Publication Type	Journal
Abbreviation	PLoS Biol.
Title	PLoS Biology
Publication Year	2003-
ISBN/ISSN	1545-7885 1544-9173
Data from Reference
Aberrations (1)
	Df(3L)X-21.2
Alleles (25)
	Avic\GFP^Scer\UAS.cUa Avic\GFP^W.3'UTR.Tub Avic\GFP^{W.mir-263a.mut.3'UTR.Tub} BacA\p35^Scer\UAS.cHa bft^6B bft²⁴ bft²²⁵ bft^{Scer\UAS.T:Disc\RFP-DsRed2} bft^unspecified bft^Δ263a bft^Δ263a-G4 mir-263b^{Scer\UAS.T:Disc\RFP-DsRed2} mir-263b^Δ mir-263b^Δ-G4 Ppyr\LUC^W.3'UTR.Tub Ppyr\LUC^{W.mir-263a.mut.3'UTR.Tub} Scer\GAL4^{bft-Δ263a-G4} Scer\GAL4^{mir-263b-Δ-G4} T:Disc\RFP^DsRed2 th^Scer\UAS.cHa W¹ W⁰⁵⁰¹⁴ W^Ala5.GMR W^d10274 W^GD1673
Constructs (11)
	P{GD1673} P{GMR-hid.Ala5} P{Tub-GFP.hid.3'UTR} P{Tub-GFP.mir-263a.mut.hid.3'UTR} P{Tub-LUC.hid.3'UTR} P{Tub-LUC.mir-263a.mut.hid.3'UTR} P{UAS-DIAP1.H} P{UAS-DsRed-mir-263a} P{UAS-DsRed-mir-263b} P{UAS-GFP.U} P{UAS-p35.H}
Genes (12)
	Avic\GFP BacA\p35 bft CG32150 CycE mir-263b Ppyr\LUC Scer\GAL4 shg sv th W
Insertions (1)
	P{XP}W^d10274
Natural transposons (1)
	P-element