Reference Report

Reference
Citation	Fernandes, I., Chanut-Delalande, H., Ferrer, P., Latapie, Y., Waltzer, L., Affolter, M., Payre, F., Plaza, S. (2010). Zona pellucida domain proteins remodel the apical compartment for localized cell shape changes. Dev. Cell 18(1): 64--76. (Export to RIS)
FlyBase ID	FBrf0211093
Publication Type	Research paper
PubMed ID	20152178
PubMed Abstract	The zona pellucida domain (ZPD) defines a conserved family of membrane-anchored matrix proteins that are, as yet, poorly characterized with respect to their functions during development. Using genetic approaches in flies, we show here that a set of eight ZPD proteins is required for the localized reorganization of embryonic epidermal cells during morphogenesis. Despite varying degrees of sequence conservation, these ZPD proteins exert specific and nonredundant functions in the remodeling of epidermal cell shape. Each one accumulates in a restricted subregion of the apical compartment, where it organizes local interactions between the membrane and the extracellular matrix. In addition, ZPD proteins are required to sculpture the actin-rich cell extensions and maintain appropriate organization of the apical compartment. These results on ZPD proteins therefore reveal a functional subcompartmentalization of the apical membrane and its role in the polarized control of epithelial cell shape during development.
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Supplementary material	Supplementary Information. [FBrf0211309]
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Dev. Cell
Title	Developmental Cell
Publication Year	2001-
ISBN/ISSN
Data from Reference
Aberrations (6)
	Df(3L)dyl^Δ26 Df(3L)zye^ex72 Df(3R)mey^Δ13 Df(3R)neo^Δ32 Df(3R)neo^Δ36 Df(3R)nyo-mey^Δ
Alleles (22)
	btd¹ cyr^Scer\UAS.cFa dyl^Scer\UAS.cFa m::tyn^{PAN-tyn.Scer\UAS} m::tyn^ZPm.Scer\UAS m::tyn^{ZPtyn.Scer\UAS} m¹ m^Scer\UAS.cFa m^{Scer\UAS.T:Arus\HRP} m^{Scer\UAS.tecta} neo^Scer\UAS.cFa nyo^Scer\UAS.cFa nyo^Δ32 nyo^Δ33 ovo^svb-1 Scer\GAL4^da.G32 tyn^ex35 tyn^PG38 tyn^Scer\UAS.cFa tyn^{ΔPAN.Scer\UAS} zye^EY05938 zye^Scer\UAS.cFa
Constructs (13)
	P{GAL4-da.G32} P{UAS-dyl.F} P{UAS-m::tyn.PAN-tyn} P{UAS-m::tyn.ZPm} P{UAS-m::tyn.ZPtyn} P{UAS-m.F} P{UAS-m.HRP} P{UAS-m.tecta} P{UAS-neo.F} P{UAS-nyo.F} P{UAS-tyn.F} P{UAS-tyn.ΔPAN} P{UAS-zye.F}
Genes (23)
	btd CG13196 CG15020 CG17111 crb cyr dlg1 dp dy dyl m m::tyn mey neo nompA nyo ovo pio qsm Scer\GAL4 shg tyn zye
Insertions (1)
	P{EPgy2}zye^EY05938