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Citation
Graham, T.G., Tabei, S.M., Dinner, A.R., Rebay, I. (2010). Modeling bistable cell-fate choices in the Drosophila eye: qualitative and quantitative perspectives.  Development 137(14): 2265--2278.
FlyBase ID
FBrf0211114
Publication Type
Review
Abstract

A major goal of developmental biology is to understand the molecular mechanisms whereby genetic signaling networks establish and maintain distinct cell types within multicellular organisms. Here, we review cell-fate decisions in the developing eye of Drosophila melanogaster and the experimental results that have revealed the topology of the underlying signaling circuitries. We then propose that switch-like network motifs based on positive feedback play a central role in cell-fate choice, and discuss how mathematical modeling can be used to understand and predict the bistable or multistable behavior of such networks.

PubMed ID
PubMed Central ID
PMC2889600 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Development
    Title
    Development
    Publication Year
    1987-
    ISBN/ISSN
    0950-1991
    Data From Reference
    Genes (7)