Reference Report

Reference
Citation	Prestel, M., Feller, C., Straub, T., Mitlöhner, H., Becker, P.B. (2010). The Activation Potential of MOF Is Constrained for Dosage Compensation. Mol. Cell 38(6): 815--826. (Export to RIS)
FlyBase ID	FBrf0211211
Publication Type	Research paper
PubMed ID	20620953
PubMed Abstract	The H4K16 acetyltransferase MOF plays a crucial role in dosage compensation in Drosophila but has additional, global functions. We compared the molecular context and effect of MOF in male and female flies, combining chromosome-wide mapping and transcriptome studies with analyses of defined reporter loci in transgenic flies. MOF distributes dynamically between two complexes, the dosage compensation complex and a complex containing MBD-R2, a global facilitator of transcription. These different targeting principles define the distribution of MOF between the X chromosome and autosomes and at transcription units with 5' or 3' enrichment. The male X chromosome differs from all other chromosomes in that H4K16 acetylation levels do not correlate with transcription output. The reconstitution of this phenomenon at a model locus revealed that the activation potential of MOF is constrained in male cells in the context of the DCC to arrive at the 2-fold activation of transcription characteristic of dosage compensation.
DOI	10.1016/j.molcel.2010.05.022
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Mol. Cell
Title	Molecular Cell
Publication Year	1997-
ISBN/ISSN	1097-2765 1097-4164
Data from Reference
Alleles (7)
	Ecol\lacZ^C4.Scer\UAS Ecol\lacZ^Scer\UAS.RC3 mof¹ mof^{T:Zzzz\FLAG,T:Scer\GAL4} msl-1^Hsp83.PC msl-2^{hs.T:Avic\GFP-Venus} w^+mC
Constructs (5)
	P{hs-msl-2.Venus} P{Hsp83-msl-1.C} P{mof-GAL4.DBD} P{UAS-lacZ.RC3} P{UAS-lacZ.U/l5}
Genes (22)
	arm Chro dgt1 Ecol\lacZ His4 Iswi MBD-R2 mof msl-1 msl-2 Mtor Nup153 pzg Rcd1 Rcd5 RpII33 scf T:Scer\GAL4 T:Zzzz\FLAG w wah wds
Natural transposons (1)
	P-element