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Citation
Zheng, X., Sehgal, A. (2010). AKT and TOR Signaling Set the Pace of the Circadian Pacemaker.  Curr. Biol. 20(13): 1203--1208.
FlyBase ID
FBrf0211221
Publication Type
Research paper
Abstract

The circadian clock coordinates cellular and organismal energy metabolism. The importance of this circadian timing system is underscored by findings that defects in the clock cause deregulation of metabolic physiology and result in metabolic disorders. On the other hand, metabolism also influences the circadian clock, such that circadian gene expression in peripheral tissues is affected in mammalian models of obesity and diabetes. However, to date there is little to no information on the effect of metabolic genes on the central brain pacemaker which drives behavioral rhythms. We have found that the AKT and TOR-S6K pathways, which are major regulators of nutrient metabolism, cell growth, and senescence, impact the brain circadian clock that drives behavioral rhythms in Drosophila. Elevated AKT or TOR activity lengthens circadian period, whereas reduced AKT signaling shortens it. Effects of TOR-S6K appear to be mediated by SGG/GSK3beta, a known kinase involved in clock regulation. Like SGG, TOR signaling affects the timing of nuclear accumulation of the circadian clock protein TIMELESS. Given that activities of AKT and TOR pathways are affected by nutrient/energy levels and endocrine signaling, these data suggest that metabolic disorders caused by nutrient and energy imbalance are associated with altered rest:activity behavior.

PubMed ID
PubMed Central ID
PMC3165196 (PMC) (EuropePMC)
Related Publication(s)
Note

Circadian Clocks and Metabolism: The Nutrient-Sensing AKT and TOR Pathways Make the Link.
Giebultowicz and Kapahi, 2010, Curr. Biol. 20(14): R608--RR609 [FBrf0211328]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Curr. Biol.
    Title
    Current Biology
    Publication Year
    1991-
    ISBN/ISSN
    0960-9822
    Data From Reference