Reference Report

Reference
Citation	Rhiner, C., López-Gay, J.M., Soldini, D., Casas-Tinto, S., Martín, F.A., Lombardía, L., Moreno, E. (2010). Flower forms an extracellular code that reveals the fitness of a cell to its neighbors in Drosophila. Dev. Cell 18(6): 985--998. (Export to RIS)
FlyBase ID	FBrf0211273
Publication Type	Research paper
PubMed ID	20627080
PubMed Abstract	Cell competition promotes the elimination of weaker cells from a growing population. Here we investigate how cells of Drosophila wing imaginal discs distinguish "winners" from "losers" during cell competition. Using genomic and functional assays, we have identified several factors implicated in the process, including Flower (Fwe), a cell membrane protein conserved in multicellular animals. Our results suggest that Fwe is a component of the cell competition response that is required and sufficient to label cells as "winners" or "losers." In Drosophila, the fwe locus produces three isoforms, fwe(ubi), fwe(Lose-A), and fwe(Lose-B). Basal levels of fwe(ubi) are constantly produced. During competition, the fwe(Lose) isoforms are upregulated in prospective loser cells. Cell-cell comparison of relative fwe(Lose) and fwe(ubi) levels ultimately determines which cell undergoes apoptosis. This "extracellular code" may constitute an ancient mechanism to terminate competitive conflicts among cells.
DOI	10.1016/j.devcel.2010.05.010
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Cell
Title	Developmental Cell
Publication Year	2001-
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Data from Reference
Aberrations (1)
	Df(3L)e70
Alleles (50)
	Ama^GD12733 Avic\GFP^Scer\UAS.cUa BacA\p35^Scer\UAS.cHa CkIIα-i1^e70 Cont^GD12610 dm^αTub84B.PBb dpp^Scer\UAS.cRa drpr^Δ5 Ecol\lacZ^Scer\UAS.cBa egr^GD12658 egr^Scer\UAS.cMa fu2^GD4113 fwe^{delC.Scer\UAS.P\T.C.T:Ivir\HA1} fwe^{delC.Scer\UAS.P\T.N.T:Ivir\HA1} fwe^{delC.Scer\UAS.P\T} fwe^e70 fwe^e122 fwe^e202 fwe^EY08496 fwe^GD4616 fwe^JF02632 fwe^KK109356 fwe^{Scer\UAS.P\T.Lose-A.C.T:Ivir\HA1} fwe^{Scer\UAS.P\T.Lose-A.N.T:Ivir\HA1} fwe^{Scer\UAS.P\T.Lose-A} fwe^{Scer\UAS.P\T.Lose-B.C.T:Ivir\HA1} fwe^{Scer\UAS.P\T.Lose-B.N.T:Ivir\HA1} fwe^{Scer\UAS.P\T.Lose-B} fwe^{Scer\UAS.P\T.ubi.C.T:Ivir\HA1} fwe^{Scer\UAS.P\T.ubi.N.T:Ivir\HA1} fwe^{Scer\UAS.P\T.ubi} Lamp1^GD1798 Rab5^Scer\UAS.cEa RpL19^unspecified Scer\GAL4^Act5C.PI Scer\GAL4^ap-md544 Scer\GAL4^en-e16E Scer\GAL4^GMR.PF Scer\GAL4^{Scer\FRT.Act5C} Scer\GAL4^{Scer\FRT.Rnor\CD2.αTub84B} Scer\GAL4^αTub84B.PBb Scer\GAL4^αTub84B.PL Scer\GAL4^αTub84B.PP Scer\GAL80^αTub84B.PL scrib¹ th^Scer\UAS.cHa tkv⁴ TMS1^GD2493 W^VDRC.cUa y^VDRC.cUa
Constructs (39)
	H{UAS-dpp.R} P{Act5C-GAL4} P{AyGAL4} P{GAL4-ninaE.GMR} P{GAL4-αTub84B(FRT.CD2).P} P{GAL4-αTub84B(-FRT).P} P{GD1798} P{GD2493} P{GD4113} P{GD4616} P{GD12610} P{GD12658} P{GD12733} P{KK109356} P{TRiP.JF02632} P{tubP-GAL4} P{tubP-GAL80} P{UAS-DIAP1.H} P{UAS-eiger.M} P{UAS-GFP.U} P{UAS-lacZ.B} P{UAS-p35.H} P{UASp-fwe.delC.HA-C} P{UASp-fwe.delC.HA-N} P{UASp-fwe.delC} P{UASp-fwe.Lose-A.HA-C} P{UASp-fwe.Lose-A.HA-N} P{UASp-fwe.Lose-A} P{UASp-fwe.Lose-B.HA-C} P{UASp-fwe.Lose-B.HA-N} P{UASp-fwe.Lose-B} P{UASp-fwe.ubi.HA-C} P{UASp-fwe.ubi.HA-N} P{UASp-fwe.ubi} P{UAS-Rab5.E} P{VDRC.W.U} P{VDRC.y.U} P{αTub84B(FRT.dm)GAL4.Bb} P{αTub84B(-FRT)GAL4.Bb}
Genes (30)
	Ama Avic\GFP BacA\p35 brk CkIIα-i1 Cont dm dpp drpr Ecol\lacZ egr fu2 fwe hep Lamp1 Rab5 repo RpL19 Scer\GAL4 Scer\GAL80 scrib T:Ivir\HA1 T:Ivir\haemagglutinin th tkv TMS1 vg W wg y
Insertions (3)
	P{en2.4-GAL4}e16E P{EPgy2}fwe^EY08496 P{GawB}ap^md544
Natural transposons (1)
	P-element