Reference Report

Reference
Citation	Buechling, T., Bartscherer, K., Ohkawara, B., Chaudhary, V., Spirohn, K., Niehrs, C., Boutros, M. (2010). Wnt/Frizzled Signaling Requires dPRR, the Drosophila Homolog of the Prorenin Receptor. Curr. Biol. 20(14): 1263--1268. (Export to RIS)
FlyBase ID	FBrf0211368
Publication Type	Research paper
PubMed ID	20579883
PubMed Abstract	Wnt/Wg signaling pathways are of key importance during development and disease. Canonical and noncanonical Wnt/Frizzled (Fz) pathways share a limited number of signaling components that are part of the membrane proximal signaling complex. In Drosophila, Fz and Dishevelled (Dsh) are the only two components known to be involved in both Wnt/beta-catenin and planar cell polarity (PCP) signaling. PCP signaling is required for the planar polarization of epithelial cells, which occurs, for instance, during hair orientation and gastrulation in vertebrates. Both pathways have been studied intensively in the past years. However, it still remains unresolved whether additional components are required at the receptor complex. Here we identify the Drosophila homolog of the mammalian prorenin receptor (dPRR) as a conserved modulator of canonical Wnt/beta-cat and Fz/PCP signaling. We show that dPRR depletion affects Wg target genes in cultured cells and in vivo. PRR is required for epithelial planar polarity in Drosophila and for convergent extension movements in Xenopus gastrulae. Furthermore, dPRR binds to Fz and Fz2 receptors. In summary, our data suggest that dPRR has an evolutionarily conserved role at the receptor level for activation of canonical and noncanonical Wnt/Fz signaling pathways.
DOI	10.1016/j.cub.2010.05.028
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Curr. Biol.
Title	Current Biology
Publication Year	1991-
ISBN/ISSN	0960-9822
Data from Reference
Alleles (14)
	fz^Scer\UAS.cAa Hsap\ATP6AP2^{Scer\UAS.T:Avic\GFP-EGFP} Scer\GAL4^ap-md544 Scer\GAL4^dpp.PS Scer\GAL4^GR1 Scer\GAL4^nub-AC-62 Scer\GAL4^ptc-559.1 T:Avic\GFP^EGFP VhaM8.9^5-HA-1890 VhaM8.9^EY03616 VhaM8.9^{EY03616-excΔ} VhaM8.9^GD2871 VhaM8.9^{Scer\UAS.BKN27676} VhaM8.9^{Scer\UAS.T:Avic\GFP-EGFP}
Constructs (6)
	P{dpp-GAL4.PS} P{GD2871} P{UAS-fz.A} P{UAS-hPRR.EGFP} P{UAS-PRR.BKN27676} P{UAS-PRR.EGFP}
Genes (14)
	arm CG6234 CkIα Fas3 fz fz2 Hsap\ATP6AP2 nkd Rel Scer\GAL4 sens stan VhaM8.9 wls
Insertions (6)
	P{EPgy2}VhaM8.9^EY03616 P{GawB}ap^md544 P{GawB}GR1 P{GawB}nubbin-AC-62 P{GawB}ptc^559.1 P{RS5}VhaM8.9^5-HA-1890
Natural transposons (1)
	P-element