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Reference Report
| Reference | |||
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| Citation | Schaefer, M., Pollex, T., Hanna, K., Tuorto, F., Meusburger, M., Helm, M., Lyko, F. (2010). RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage. Genes Dev. 24(15): 1590--1595. (Export to RIS) | ||
| FlyBase ID | FBrf0211424 | ||
| Publication Type | Research paper | ||
| PubMed ID | 20679393 | ||
| PubMed Abstract | Dnmt2 proteins are the most conserved members of the DNA methyltransferase enzyme family, but their substrate specificity and biological functions have been a subject of controversy. We show here that, in addition to tRNA(Asp-GTC), tRNA(Val-AAC) and tRNA(Gly-GCC) are also methylated by Dnmt2. Drosophila Dnmt2 mutants showed reduced viability under stress conditions, and Dnmt2 relocalized to stress granules following heat shock. Strikingly, stress-induced cleavage of tRNAs was Dnmt2-dependent, and Dnmt2-mediated methylation protected tRNAs against ribonuclease cleavage. These results uncover a novel biological function of Dnmt2-mediated tRNA methylation, and suggest a role for Dnmt2 enzymes during the biogenesis of tRNA-derived small RNAs. | ||
| DOI | 10.1101/gad.586710 | ||
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| Secondary IDs | |||
| Language of Publication | English | ||
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Parent Publication
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| Publication Type | Journal | ||
| Abbreviation | Genes Dev. | ||
| Title | Genes & Development | ||
| Publication Year | 1987- | ||
| ISBN/ISSN | 0890-9369 | ||
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Data from Reference
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| Alleles (4)
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| Constructs (3)
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| Genes (43)
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| Insertions (2)
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| Natural transposons (1)
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| Polypeptides (1)
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