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| Reference | |||
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| Citation | Huang, H., Yu, Z., Zhang, S., Liang, X., Chen, J., Li, C., Ma, J., Jiao, R. (2010). Drosophila CAF-1 regulates HP1-mediated epigenetic silencing and pericentric heterochromatin stability. J. Cell Sci. 123(16): 2853--2861. (Export to RIS) | ||
| FlyBase ID | FBrf0211452 | ||
| Publication Type | Research paper | ||
| PubMed ID | 20663913 | ||
| PubMed Abstract | Chromatin assembly factor 1 (CAF-1) was initially characterized as a histone deliver in the process of DNA-replication-coupled chromatin assembly in eukaryotic cells. Here, we report that CAF-1 p180, the largest subunit of Drosophila CAF-1, participates in the process of heterochromatin formation and functions to maintain pericentric heterochromatin stability. We provide evidence that Drosophila CAF-1 p180 plays a role in both classes of position effect variegation (PEV) and in the expression of heterochromatic genes. A decrease in the expression of Drosophila CAF-1 p180 leads to a decrease in both H3K9 methylation at pericentric heterochromatin regions and the recruitment of heterochromatin protein 1 (HP1) to the chromocenter of the polytene chromosomes. The artificial targeting of HP1 to a euchromatin location leads to the enrichment of Drosophila CAF-1 p180 at this ectopic heterochromatin, suggesting the mutual recruitment of HP1 and CAF-1 p180. We also show that the spreading of heterochromatin is compromised in flies that have reduced CAF-1 p180. Furthermore, reduced CAF-1 p180 causes a defect in the dynamics of heterochromatic markers in early Drosophila embryos. Together, these findings suggest that Drosophila CAF-1 p180 is an essential factor in the epigenetic control of heterochromatin formation and/or maintenance. | ||
| DOI | 10.1242/jcs.063610 | ||
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| Language of Publication | English | ||
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| Publication Type | Journal | ||
| Abbreviation | J. Cell Sci. | ||
| Title | Journal of Cell Science | ||
| Publication Year | 1966- | ||
| ISBN/ISSN | 0021-9533 | ||
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Data from Reference
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| Genes (12)
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