Reference Report

Reference
Citation	Pauls, D., Selcho, M., Gendre, N., Stocker, R.F., Thum, A.S. (2010). Drosophila Larvae Establish Appetitive Olfactory Memories via Mushroom Body Neurons of Embryonic Origin. J. Neurosci. 30(32): 10655--10666. (Export to RIS)
FlyBase ID	FBrf0211533
Publication Type	Research paper
PubMed ID	20702697
PubMed Abstract	Insect mushroom bodies are required for diverse behavioral functions, including odor learning and memory. Using the numerically simple olfactory pathway of the Drosophila melanogaster larva, we provide evidence that the formation of appetitive olfactory associations relies on embryonic-born intrinsic mushroom body neurons (Kenyon cells). The participation of larval-born Kenyon cells, i.e., neurons that become gradually integrated in the developing mushroom body during larval life, in this task is unlikely. These data provide important insights into how a small set of identified Kenyon cells can store and integrate olfactory information in a developing brain. To investigate possible functional subdivisions of the larval mushroom body, we anatomically disentangle its input and output neurons at the single-cell level. Based on this approach, we define 10 subdomains of the larval mushroom body that may be implicated in mediating specific interactions between the olfactory pathway, modulatory neurons, and neuronal output.
DOI	10.1523/JNEUROSCI.1281-10.2010
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Language of Publication	English
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Publication Type	Journal
Abbreviation	J. Neurosci.
Title	Journal of Neuroscience
Publication Year	1981-
ISBN/ISSN	0270-6474 1529-2401
Data from Reference
Alleles (16)
	Disc\RFP^Mef2.mb247 Dscam^{exon17.1.Scer\UAS.T:Avic\GFP} Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} n-syb^{Scer\UAS.cYa.T:Avic\GFP} Scer\GAL4^amn-NP2447 Scer\GAL4^c305a Scer\GAL4^c503 Scer\GAL4^D52H Scer\GAL4^dnc-NP3128 Scer\GAL4^GH146 Scer\GAL4^Mef2.247 Scer\GAL4^NP1131 Scer\GAL4^ple.PF Scer\GAL4^Tab2-201Y Scer\GAL80^Mef2.PT shi^1.Scer\UAS
Constructs (9)
	P{dnc-GAL4.D52H} P{mb247-DsRed} P{Mef2-GAL4.247} P{Mef2-GAL80.T} P{ple-GAL4.F} P{UAS(-FRT)n-syb-GFP.Y} P{UAS-Dscam.exon17.1.GFP} P{UAS-mCD8::GFP.L} P{UAS-shi^ts1.K}
Genes (9)
	Cha Disc\RFP Dscam Fas2 Mmus\Cd8a n-syb Scer\GAL4 Scer\GAL80 shi
Insertions (7)
	P{GAL4}c503 P{GawB}amn^NP2447 P{GawB}c305a P{GawB}dnc^NP3128 P{GawB}GH146 P{GawB}NP1131 P{GawB}Tab2^201Y
Natural transposons (1)
	P-element