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Citation
Parry, T.J., Theisen, J.W., Hsu, J.Y., Wang, Y.L., Corcoran, D.L., Eustice, M., Ohler, U., Kadonaga, J.T. (2010). The TCT motif, a key component of an RNA polymerase II transcription system for the translational machinery.  Genes Dev. 24(18): 2013--2018.
FlyBase ID
FBrf0211834
Publication Type
Research paper
Abstract

The TCT motif (polypyrimidine initiator) encompasses the transcription start site of nearly all ribosomal protein genes in Drosophila and mammals. The TCT motif is required for transcription of ribosomal protein gene promoters. The TCT element resembles the Inr (initiator), but is not recognized by TFIID and cannot function in lieu of an Inr. However, a single T-to-A substitution converts the TCT element into a functionally active Inr. Thus, the TCT motif is a novel transcriptional element that is distinct from the Inr. These findings reveal a specialized TCT-based transcription system that is directed toward the synthesis of ribosomal proteins.

PubMed ID
PubMed Central ID
PMC2939363 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genes Dev.
    Title
    Genes & Development
    Publication Year
    1987-
    ISBN/ISSN
    0890-9369
    Data From Reference
    Genes (14)