Reference Report

Reference
Citation	Repiso, A., Saavedra, P., Casal, J., Lawrence, P.A. (2010). Planar cell polarity: the orientation of larval denticles in Drosophila appears to depend on gradients of Dachsous and Fat. Development 137(20): 3411--3415. (Export to RIS)
FlyBase ID	FBrf0211889
Publication Type	Research paper
PubMed ID	20826534
PubMed Abstract	The larval ventral belts of Drosophila consist of six to seven rows of denticles that are oriented, some pointing forwards, some backwards. We present evidence that denticle orientation is determined almost entirely by Dachsous and Fat, one of two planar cell polarity systems. If we change the distribution of Dachsous we can alter the polarity of denticles. We suggest that the orientation of the individual denticle rows, in both the anterior compartment (which mostly point backwards) and the posterior compartment (which point forwards), is determined by the opposing slopes of a Dachsous/Fat gradient. We show, by altering the concentration gradients of Dachsous during development, that we can change the polarity of the denticles made by larval cells as they progress between the first and third larval instars without mitosis.
DOI	10.1242/dev.047126
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Alleles (12)
	Act5C^{Scer\UAS.T:Avic\GFP} ds^{ecto.Scer\UAS} ds^Scer\UAS.cTa ds^UAO71 ft¹² ft¹⁵ ft^Scer\UAS.cMa fz^Scer\UAS.cZa Scer\GAL4^arm.PS Scer\GAL4^en-e16E Scer\GAL4^ptc-559.1 Scer\GAL80^ts.αTub84B
Constructs (7)
	P{GAL4-arm.S} P{tubP-GAL80^ts} P{UAS-Act5C.T:GFP} P{UAS-ds.ecto} P{UAS-ds.T} P{UAS-ft.M} P{UAS-fz.Z}
Genes (6)
	Act5C ds ft fz Scer\GAL4 Scer\GAL80
Insertions (2)
	P{en2.4-GAL4}e16E P{GawB}ptc^559.1