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Citation
Gonzales, E., Yin, J. (2010). Drosophila Models of Huntington's Disease Exhibit Sleep Abnormalities.  PLoS Curr. (): .
FlyBase ID
FBrf0211937
Publication Type
Research paper
Abstract

The complex pathology of neurodegenerative diseases presents a challenge to researchers who model the disease, and clinicians who treat patients. The identification of early, perhaps even prodromal, biomarkers is important for developing strategies to ameliorate disease progression. Sleep disturbances are a clinical feature of Huntington's disease (HD) as well as a part of normal aging. Whether sleep dysfunctions in HD patients are epiphenomenal or central to the neurodegenerative disease process is unclear. We show that sleep fragmentation is shared among Drosophila transgenic models that express mutant forms of huntingtin (mHtt), and flies with RNAi-mediated knockdown of the endogenous gene (dhtt). Our data suggest that sleep disturbances in HD may represent loss of function in the endogenous dhtt gene and that sleep perturbations in Drosophila HD models present an opportunity for screening therapeutic interventions.

PubMed ID
PubMed Central ID
PMC2947800 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    PLoS Curr.
    Title
    PLoS currents
    ISBN/ISSN
    2157-3999
    Data From Reference
    Alleles (5)
    Genes (3)
    Human Disease Models (1)
    Transgenic Constructs (5)