Reference Report

Reference
Citation	Deng, H., Bell, J.B., Simmonds, A.J. (2010). Vestigial is required during late-stage muscle differentiation in Drosophila melanogaster embryos. Mol. Biol. Cell 21(19): 3304--3316. (Export to RIS)
FlyBase ID	FBrf0211962
Publication Type	Research paper
PubMed ID	20685961
PubMed Abstract	The somatic muscles of Drosophila develop in a complex pattern that is repeated in each embryonic hemi-segment. During early development, progenitor cells fuse to form a syncytial muscle, which further differentiates via expression of muscle-specific factors that induce specific responses to external signals to regulate late-stage processes such as migration and attachment. Initial communication between somatic muscles and the epidermal tendon cells is critical for both of these processes. However, later establishment of attachments between longitudinal muscles at the segmental borders is largely independent of the muscle-epidermal attachment signals, and relatively little is known about how this event is regulated. Using a combination of null mutations and a truncated version of Sd that binds Vg but not DNA, we show that Vestigial (Vg) is required in ventral longitudinal muscles to induce formation of stable intermuscular attachments. In several muscles, this activity may be independent of Sd. Furthermore, the cell-specific differentiation events induced by Vg in two cells fated to form attachments are coordinated by Drosophila epidermal growth factor signaling. Thus, Vg is a key factor to induce specific changes in ventral longitudinal muscles 1-4 identity and is required for these cells to be competent to form stable intermuscular attachments with each other.
DOI	10.1091/mbc.E10-04-0364
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Mol. Biol. Cell
Title	Molecular Biology of the Cell
Publication Year	1992-
ISBN/ISSN	1059-1524
Data from Reference
Alleles (21)
	btl::Egfr^{Scer\UAS.T:λ\cI-DD} Ecol\lacZ^Scer\UAS.cBa Egfr^DN.Scer\UAS Grip^ex36 rhea¹ robo¹ robo^Scer\UAS.cKa Scer\GAL4^ap-md544 Scer\GAL4^C23 Scer\GAL4^Mef2.PR Scer\GAL4^sd-SG29.1 Scer\GAL4^tey-5053A Scer\GAL4^twi.PG sd⁹ sd^{Δ88-159.Scer\UAS} sli² vg^1.Scer\UAS vg^2.Scer\UAS vg^3.Scer\UAS vg^null vg^{Scer\UAS.T:Ivir\HA1}
Constructs (11)
	P{GAL4-Mef2.R} P{GAL4-twi.G} P{UAS-Egfr.DN} P{UAS-Egfr.λtop} P{UAS-lacZ.B} P{UAS-robo.K} P{UAS-sd.Δ88-159} P{UAS-vg.1} P{UAS-vg.2} P{UAS-vg.3} P{UAS-vg.3xHA}
Genes (15)
	btl::Egfr Ecol\lacZ Egfr Grip kon mys rhea robo Scer\GAL4 sd sli stck Tig Tsp vg
Insertions (4)
	P{GawB}ap^md544 P{GawB}C23 P{GawB}sd^SG29.1 P{GawB}tey^5053A
Natural transposons (1)
	P-element