Reference Report

Reference
Citation	Kugler, S.J., Nagel, A.C. (2010). A novel Pzg-NURF complex regulates Notch target gene activity. Mol. Biol. Cell 21(19): 3443--3448. (Export to RIS)
FlyBase ID	FBrf0211977
Publication Type	Research paper
PubMed ID	20685964
PubMed Abstract	Drosophila putzig was identified as a member of the TRF2-DREF complex that is involved in core promoter selection. Additionally, putzig regulates Notch signaling, however independently of DREF. Here, we show that Putzig associates with the NURF complex. Loss of any NURF component including the NURF-specific subunit Nurf 301 impedes binding of Putzig to Notch target genes, suggesting that NURF recruits Putzig to these sites. Accordingly, Putzig can be copurified with any NURF member. Moreover, Nurf 301 mutants show reduced Notch target gene activity and enhance Notch mutant phenotypes. These data suggest a novel Putzig-NURF chromatin complex required for epigenetic activation of Notch targets.
DOI	10.1091/mbc.E10-03-0212
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Mol. Biol. Cell
Title	Molecular Biology of the Cell
Publication Year	1992-
ISBN/ISSN	1059-1524
Data from Reference
Aberrations (1)
	Df(1)N-54l9
Alleles (15)
	Caf1^GD11258 E(bx)^GD10909 E(bx)^Nurf301-2 Ecol\lacZ^{E(spl).-1166+87} Ecol\lacZ^vg.int2.1 Iswi² N^55e11 Nurf-38¹ Nurf-38^GD1625 pzg^{dsRNA.Scer\UAS} Scer\GAL4^bi-omb-Gal4 Scer\GAL4^da.G32 Scer\GAL4^en-e16E Scer\GAL4^ptc-559.1 Scer\GAL4^sd-SG29.1
Constructs (7)
	P{GAL4-da.G32} P{GD1625} P{GD10909} P{GD11258} P{m8-lacZ} P{UAS-pzg.RNAi} P{vg(D/V)-lacZ}
Genes (13)
	Caf1 ci ct E(bx) E(spl)m8-HLH Ecol\lacZ Iswi N Nurf-38 pzg Scer\GAL4 vg wg
Insertions (7)
	P{en2.4-GAL4}e16E P{GAL4}bi^omb-Gal4 P{GawB}ptc^559.1 P{GawB}sd^SG29.1 P{GD1625}v3200 P{GD10909}v24740 P{GD11258}v26455