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Zhang, M., Zhang, Y., Xu, Z. (2010). POSH is involved in Eiger-Basket (TNF-JNK) signaling and embryogenesis in Drosophila.  J. Genet. Genomics 37(9): 605--619.
FlyBase ID
FBrf0211992
Publication Type
Research paper
Abstract
TNF╬▒ can trigger different signaling pathways, including the JNK pathway, to regulate various biological functions such as cell death, differentiation and proliferation. The scaffold protein POSH (Plenty of SH3 Domains) has been shown to be an important regulator of the JNK pathway, but whether it is involved in TNF-signaling has not been reported. Although POSH has been implicated to play a role in development in zebrafish, it has not been studied in null mutants and the underlying mechanism of its effects is still not clear. In this study, we provide evidence that the JNK pathway scaffold protein, POSH, is involved in TNF (Eiger) signaling in Drosophila. POSH is likely to act downstream of dTAB2 and upstream of dTAK1 in the TNF-JNK signaling pathway. In addition, we found that POSH is essential during Drosophila embryogenesis, including epidermal dorsal closure, similar to other JNK pathway components such as Silpper, Hemipterous, and Basket. We observed defects in F-actin accumulation and adherens junction formation during dorsal closure in different posh null mutants, suggesting that POSH is required for epidermal cell migration and cell-shape change during epidermal dorsal closure.
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    J. Genet. Genomics
    Title
    Journal of Genetics and Genomics [Yi chuan xue bao]
    Publication Year
    2007--
    ISBN/ISSN
    1673-8527
    Data From Reference