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Citation
Tipping, M., Kim, Y., Kyriakakis, P., Tong, M., Shvartsman, S.Y., Veraksa, A. (2010). β-arrestin Kurtz inhibits MAPK and Toll signalling in Drosophila development.  EMBO J. 29(19): 3222--3235.
FlyBase ID
FBrf0211995
Publication Type
Research paper
Abstract

β-Arrestins have been implicated in the regulation of multiple signalling pathways. However, their role in organism development is not well understood. In this study, we report a new in vivo function of the Drosophila β-arrestin Kurtz (Krz) in the regulation of two distinct developmental signalling modules: MAPK ERK and NF-κB, which transmit signals from the activated receptor tyrosine kinases (RTKs) and the Toll receptor, respectively. Analysis of the expression of effectors and target genes of Toll and the RTK Torso in krz maternal mutants reveals that Krz limits the activity of both pathways in the early embryo. Protein interaction studies suggest a previously uncharacterized mechanism for ERK inhibition: Krz can directly bind and sequester an inactive form of ERK, thus preventing its activation by the upstream kinase, MEK. A simultaneous dysregulation of different signalling systems in krz mutants results in an abnormal patterning of the embryo and severe developmental defects. Our findings uncover a new in vivo function of β-arrestins and present a new mechanism of ERK inhibition by the Drosophila β-arrestin Krz.

PubMed ID
PubMed Central ID
PMC2957207 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    EMBO J.
    Title
    The EMBO Journal
    Publication Year
    1982-
    ISBN/ISSN
    0261-4189
    Data From Reference
    Alleles (6)
    Gene Groups (2)
    Genes (13)
    Physical Interactions (8)
    Cell Lines (1)
    Natural transposons (1)
    Transgenic Constructs (5)