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Citation
Saulière, J., Haque, N., Harms, S., Barbosa, I., Blanchette, M., Le Hir, H. (2010). The exon junction complex differentially marks spliced junctions.  Nat. Struct. Mol. Biol. 17(10): 1269--1271.
FlyBase ID
FBrf0212018
Publication Type
Research paper
Abstract

The exon junction complex (EJC), which is deposited onto mRNAs as a consequence of splicing, is involved in multiple post-transcriptional events in metazoa. Here, using Drosophila melanogaster cells, we show that only some introns trigger EJC-dependent nonsense-mediated mRNA decay and that EJC association with particular spliced junctions depends on RNA cis-acting sequences. This study provides the first evidence to our knowledge that EJC deposition is not constitutive but instead is a regulated process.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nat. Struct. Mol. Biol.
    Title
    Nature Structural and Molecular Biology
    Publication Year
    2004-
    ISBN/ISSN
    1545-9993 1545-9985
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