Reference Report

Reference
Citation	Filion, G.J., van Bemmel, J.G., Braunschweig, U., Talhout, W., Kind, J., Ward, L.D., Brugman, W., de Castro, I.J., Kerkhoven, R.M., Bussemaker, H.J., van Steensel, B. (2010). Systematic protein location mapping reveals five principal chromatin types in Drosophila cells. Cell 143(2): 212--224. (Export to RIS)
FlyBase ID	FBrf0212051
Publication Type	Research paper
PubMed ID	20888037
PubMed Abstract	Chromatin is important for the regulation of transcription and other functions, yet the diversity of chromatin composition and the distribution along chromosomes are still poorly characterized. By integrative analysis of genome-wide binding maps of 53 broadly selected chromatin components in Drosophila cells, we show that the genome is segmented into five principal chromatin types that are defined by unique yet overlapping combinations of proteins and form domains that can extend over > 100 kb. We identify a repressive chromatin type that covers about half of the genome and lacks classic heterochromatin markers. Furthermore, transcriptionally active euchromatin consists of two types that differ in molecular organization and H3K36 methylation and regulate distinct classes of genes. Finally, we provide evidence that the different chromatin types help to target DNA-binding factors to specific genomic regions. These results provide a global view of chromatin diversity and domain organization in a metazoan cell.
DOI	10.1016/j.cell.2010.09.009
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Genes (55)
	Act5C asf1 ash2 bcd BEAF-32 brm Caf1 Cdk7 CG42724 CtBP CTCF D1 Df31 Dsp1 dwg E(z) EcR eff Gcn5 gro His1 His3 HP1c HP6 ial Jra Lam Lhr lolal Max MED31 Mnt MRG15 mus209 Pc Pcl pho phol prod Rpd3 RpII18 Sce Sin3A Sir2 su(Hw) Su(var)2-10 Su(var)3-7 Su(var)3-9 Su(var)205 SuUR Tbp Tip60 Top1 Trl w
Libraries/Collections (1)
	Chromatin_types_NKI.Kc167