Reference Report

Reference
Citation	de Navascués, J., Modolell, J. (2010). The pronotum LIM-HD gene tailup is both a positive and a negative regulator of the proneural genes achaete and scute of Drosophila. Mech. Dev. 127(9-12): 393--406. (Export to RIS)
FlyBase ID	FBrf0212072
Publication Type	Research paper
PubMed ID	20580820
PubMed Abstract	Early in the development of the imaginal wing disc of Drosophila, the LIM-HD gene tailup (islet), together with the HD genes of the iroquois complex, specify the notum territory of the disc. Later, tailup has been shown to act as a prepattern gene that antagonizes formation of sensory bristles on the notum of this fly. It has been proposed that Tailup downregulates the expression of the proneural genes achaete and scute by interfering with factors needed to activate these genes in the dorsocentral and scutellar regions of the disc. By means of a clonal analysis performed with tailup null alleles, here we show that, on the one hand, tailup is necessary to prevent formation of extra macrochaetae on most of the 11 sites where these landmark bristles arise on the fly notum. On the other hand, tailup is required to activate achaete and scute at the dorsocentral region, probably by acting as an hexameric complex with the cofactor Chip and the transcriptional activator Sspd on the dorsocentral enhancer of the achaete-scute complex. In contrast, in the scutellar region Tailup acts downstream of achaete-scute, antagonizing the proneural function of these genes probably in cooperation with Chip. We conclude that tailup acts on bristle development by several, even antagonistic, mechanisms.
DOI	10.1016/j.mod.2010.05.001
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Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Mech. Dev.
Title	Mechanisms of Development
Publication Year	1990-
ISBN/ISSN	0925-4773
Data from Reference
Alleles (22)
	Chi^e5.5 Chi^E Dcr-2^Scer\UAS.cDa Ecol\lacZ^ac.AS1.4DC Ecol\lacZ^ac.AX2.3DC pnr^Scer\UAS.cHa sc^A sc^ase-1 sc^Scer\UAS.cPa Scer\GAL4^C-765 Scer\GAL4^MS248 Scer\GAL4^pnr-MD237 Scer\GAL4^tup-JQ3 Ssdp^neo48 t^Scer\UAS.cTa tup² tup^d03613 tup^{dsRNA.Scer\UAS} tup^ex4 tup^isl-1 tup^JQ3 y^Scer\UAS.cCa
Constructs (9)
	P{ac-lacZ.AS1.4DC} P{ac-lacZ.AX2.3DC} P{GawB} P{UAS-Dcr-2.D} P{UAS-pnr.H} P{UAS-sc.P} P{UAS-t.T} P{UAS-tup.IR} P{UAS-y.C}
Genes (14)
	ac Chi Dcr-2 Ecol\lacZ eyg pnr RpS3 sc Scer\GAL4 sens Ssdp t tup y
Insertions (6)
	P{GawB}C-765 P{GawB}MS248 P{GawB}pnr^MD237 P{GawB}tup^JQ3 P{hsneo}Ssdp^neo48 P{XP}tup^d03613
Natural transposons (1)
	P-element