Reference Report

Reference
Citation	Song, J.K., Kannan, R., Merdes, G., Singh, J., Mlodzik, M., Giniger, E. (2010). Disabled is a bona fide component of the Abl signaling network. Development 137(21): 3719--3727. (Export to RIS)
FlyBase ID	FBrf0212092
Publication Type	Research paper
PubMed ID	20940230
PubMed Abstract	Abl is an essential regulator of cell migration and morphogenesis in both vertebrates and invertebrates. It has long been speculated that the adaptor protein Disabled (Dab), which is a key regulator of neuronal migration in the vertebrate brain, might be a component of this signaling pathway, but this idea has been controversial. We now demonstrate that null mutations of Drosophila Dab result in phenotypes that mimic Abl mutant phenotypes, both in axon guidance and epithelial morphogenesis. The Dab mutant interacts genetically with mutations in Abl, and with mutations in the Abl accessory factors trio and enabled (ena). Genetic epistasis tests show that Dab functions upstream of Abl and ena, and, consistent with this, we show that Dab is required for the subcellular localization of these two proteins. We therefore infer that Dab is a bona fide component of the core Abl signaling pathway in Drosophila.
DOI	10.1242/dev.050948
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (2)
	Df(3L)st100.62 In(3L)std11
Alleles (12)
	Abl² Abl⁴ Abl^Scer\UAS.cFa Dab¹ Dab² Dab^Scer\UAS.cWa ena^GC1 ena^GC5 Scer\GAL4^elav.PU Scer\GAL4^sca-537.4 trio¹ trio⁸
Constructs (3)
	P{elav-GAL4.U} P{UAS-Abl.F} P{UAS-Dab.W}
Genes (8)
	Abl Dab elav ena Fas2 Lasp Scer\GAL4 trio
Insertions (3)
	P{EPgy2}Dab^EY10190 P{GawB}sca^537.4 P{XP}Dab^d11255