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Citation
Zhang, Y.E., Vibranovski, M.D., Krinsky, B.H., Long, M. (2010). Age-dependent chromosomal distribution of male-biased genes in Drosophila.  Genome Res. 20(11): 1526--1533.
FlyBase ID
FBrf0212213
Publication Type
Research paper
Abstract

We investigated the correlation between the chromosomal location and age distribution of new male-biased genes formed by duplications via DNA intermediates (DNA-level) or by de novo origination in Drosophila. Our genome-wide analysis revealed an excess of young X-linked male-biased genes. The proportion of X-linked male-biased genes then diminishes through time, leading to an autosomal excess of male-biased genes. The switch between X-linked and autosomal enrichment of male-biased genes was also present in the distribution of both protein-coding genes on the D. pseudoobscura neo-X chromosome and microRNA genes of D. melanogaster. These observations revealed that the evolution of male-biased genes is more complicated than the previously detected one-step X→A gene traffic and the enrichment of the male-biased genes on autosomes. The pattern we detected suggests that the interaction of various evolutionary forces such as the meiotic sex chromosome inactivation (MSCI), faster-X effect, and sexual antagonism in the male germline might have shaped the chromosomal distribution of male-biased genes on different evolutionary time scales.

PubMed ID
PubMed Central ID
PMC2963816 (PMC) (EuropePMC)
Related Publication(s)
Supplementary material
FlyBase analysis

Summary of published retrogene analyses.
dos Santos, 2014, Summary of published retrogene analyses. [FBrf0225799]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genome Res.
    Title
    Genome Research
    Publication Year
    1995-
    ISBN/ISSN
    1088-9051
    Data From Reference